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@PHDTHESIS{Korvasov:911034,
      author       = {Korvasová, Karolína},
      title        = {{P}ersistent firing and oscillations in the
                      septo-hippocampal system and their relation to locomotion},
      volume       = {86},
      school       = {RWTH Aachen University},
      type         = {Dissertation},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2022-04360},
      isbn         = {978-3-95806-654-0},
      series       = {Schriften des Forschungszentrums Jülich Reihe Information
                      / Information},
      year         = {2022},
      note         = {Dissertation, RWTH Aachen University, 2022},
      abstract     = {The medial septum, diagonal band of Broca has received most
                      attention as a putative pacemaker of the hippocampal theta
                      rhythm. However, due to its high interconnectivity with
                      various cortical and subcortical regions, the medial septum
                      is involved in a variety of neural processes. This thesis
                      focuses on the relation between medial septal spiking
                      activity, hippocampal theta rhythm and locomotion. It was
                      previously demonstrated that theta-periodic optogenetic
                      activation of medial septal glutamatergic neurons entrains
                      hippocampal theta oscillation and initiates
                      persistentlocomotion of the animal. We showed that
                      hippocampal theta oscillation and locomotion, both
                      persisting after the stimulus offset, can be induced by a
                      brief continuous light stimulation of medial septal
                      glutamatergic neurons. The hippocampal theta rhythm is not
                      necessary for inducing persistent locomotion, as locomotion
                      initiation is not affected by blocking synaptic transmission
                      in the medial septum that abolishes the hippocampal theta.
                      Furthermore, we observed persistent spiking activity of the
                      medial septal neurons, lasting for many seconds after the
                      stimulus offset.To test whether the persistent activity is
                      generated locally in the medial septum, we repeated the
                      stimulation experiment in an acute medial septal slice
                      preparation. The persistent activity had a shorter duration
                      than in vivo, but was present both in the intact slice and
                      with blocked synaptic transmission, indicating that the
                      persistent firing is a result of intrinsic dynamics of
                      medial septal glutamatergic neurons. Further analysis of
                      spontaneous spiking activity of neurons in the acute medial
                      septal slice preparation revealed the existence of
                      theta-rhythmic neurons that synchronizetheir firing,
                      suggesting that the medial septum can generate the theta
                      oscillation independently of external feedforward and
                      feedback input. Even though medial septal synaptic
                      connectivity is necessary for the hippocampal theta rhythm,
                      our results suggest that the theta-rhythmic firing is a
                      result of intrinsic cellular dynamics and a low level of
                      synchrony can be achieved without synaptic coupling. It
                      remains an open question how the septal theta-rhythmic input
                      is transformed into a travelling theta wave observed in the
                      hippocampus. The last part of the thesis offers a framework
                      for studying the generation of periodic travelling waves in
                      spiking neural networks. We developed a parameter mapping
                      between a discrete network of neurons and apopulation model
                      that describes the spatio-temporal spread of activity as a
                      continuousprocess. Using this mapping, we derived conditions
                      for the existence of periodictravelling waves in the spiking
                      neural network.},
      cin          = {INM-6 / IAS-6},
      cid          = {I:(DE-Juel1)INM-6-20090406 / I:(DE-Juel1)IAS-6-20130828},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:0001-2022112351},
      url          = {https://juser.fz-juelich.de/record/911034},
}