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@ARTICLE{Rollenhagen:911048,
      author       = {Rollenhagen, Astrid and Anstötz, Max and Zimmermann,
                      Kerstin and Kasugai, Yu and Sätzler, Kurt and Molnar, Elek
                      and Ferraguti, Francesco and Lübke, Joachim H R},
      title        = {{L}ayer-specific distribution and expression pattern of
                      {AMPA}- and {NMDA}-type glutamate receptors in the barrel
                      field of the adult rat somatosensory cortex: a quantitative
                      electron microscopic analysis},
      journal      = {Cerebral cortex},
      volume       = {2022},
      issn         = {1047-3211},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2022-04374},
      pages        = {bhac212},
      year         = {2022},
      abstract     = {AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
                      acid) and NMDA (N-methyl-d-aspartate) glutamate receptors
                      are driving forces for synaptic transmission and plasticity
                      at neocortical synapses. However, their distribution pattern
                      in the adult rat neocortex is largely unknown and was
                      quantified using freeze fracture replication combined with
                      postimmunogold-labeling. Both receptors were co-localized at
                      layer (L)4 and L5 postsynaptic densities (PSDs). At L4
                      dendritic shaft and spine PSDs, the number of gold grains
                      detecting AMPA was similar, whereas at L5 shaft PSDs
                      AMPA-receptors outnumbered those on spine PSDs. Their number
                      was significantly higher at L5 vs. L4 PSDs. At L4 and L5
                      dendritic shaft PSDs, the number of gold grains detecting
                      GluN1 was ~2-fold higher than at spine PSDs. The number of
                      gold grains detecting the GluN1-subunit was higher for both
                      shaft and spine PSDs in L5 vs. L4. Both receptors showed a
                      large variability in L4 and L5. A high correlation between
                      the number of gold grains and PSD size for both receptors
                      and targets was observed. Both receptors were distributed
                      over the entire PSD but showed a layer- and target-specific
                      distribution pattern.The layer- and target-specific
                      distribution of AMPA and GluN1 glutamate receptors partially
                      contribute to the observed functional differences in
                      synaptic transmission and plasticity in the neocortex.},
      cin          = {INM-10},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-10-20170113},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35732315},
      UT           = {WOS:000814363100001},
      doi          = {10.1093/cercor/bhac212},
      url          = {https://juser.fz-juelich.de/record/911048},
}