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| 100 | 1 | _ | |a Rollenhagen, Astrid |0 P:(DE-Juel1)131704 |b 0 |
| 245 | _ | _ | |a Layer-specific distribution and expression pattern of AMPA- and NMDA-type glutamate receptors in the barrel field of the adult rat somatosensory cortex: a quantitative electron microscopic analysis |
| 260 | _ | _ | |a Oxford |c 2022 |b Oxford Univ. Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA (N-methyl-d-aspartate) glutamate receptors are driving forces for synaptic transmission and plasticity at neocortical synapses. However, their distribution pattern in the adult rat neocortex is largely unknown and was quantified using freeze fracture replication combined with postimmunogold-labeling. Both receptors were co-localized at layer (L)4 and L5 postsynaptic densities (PSDs). At L4 dendritic shaft and spine PSDs, the number of gold grains detecting AMPA was similar, whereas at L5 shaft PSDs AMPA-receptors outnumbered those on spine PSDs. Their number was significantly higher at L5 vs. L4 PSDs. At L4 and L5 dendritic shaft PSDs, the number of gold grains detecting GluN1 was ~2-fold higher than at spine PSDs. The number of gold grains detecting the GluN1-subunit was higher for both shaft and spine PSDs in L5 vs. L4. Both receptors showed a large variability in L4 and L5. A high correlation between the number of gold grains and PSD size for both receptors and targets was observed. Both receptors were distributed over the entire PSD but showed a layer- and target-specific distribution pattern.The layer- and target-specific distribution of AMPA and GluN1 glutamate receptors partially contribute to the observed functional differences in synaptic transmission and plasticity in the neocortex. |
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| 700 | 1 | _ | |a Ferraguti, Francesco |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Lübke, Joachim H R |0 P:(DE-Juel1)131696 |b 7 |e Corresponding author |
| 773 | _ | _ | |a 10.1093/cercor/bhac212 |g p. bhac212 |0 PERI:(DE-600)1483485-6 |p bhac212 |t Cerebral cortex |v 2022 |y 2022 |x 1047-3211 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/911048/files/Invoice_E15264642.pdf |
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