% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kirschner:911339,
      author       = {Kirschner, Matthias and Paquola, Casey and Khundrakpam,
                      Budhachandra S. and Vainik, Uku and Bhutani, Neha and
                      Benazir-Hodzic-Santor and Al-Sharif, Noor B. and Misic,
                      Bratislav and Bernhardt, Boris and Evans, Alan C. and
                      Dagher, Alain},
      title        = {{S}chizophrenia polygenic risk during typical development
                      reflects multiscale cortical organization},
      journal      = {Biological psychiatry: global open science},
      volume       = {3},
      number       = {4},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2022-04631},
      pages        = {1083-1093},
      year         = {2023},
      abstract     = {Schizophrenia is widely recognized as a neurodevelopmental
                      disorder, but determining neurodevelopmental features of
                      schizophrenia requires a departure from classic case-control
                      designs. Polygenic risk scoring for schizophrenia (PRS-SCZ)
                      enables investigation of the influence of genetic risk for
                      schizophrenia on cortical anatomy during neurodevelopment
                      and prior to disease onset. PRS-SCZ and cortical morphometry
                      were assessed in typically developing children (3 – 21
                      years) using T1-weighted MRI and whole genome genotyping
                      (n=390) from the Pediatric Imaging, Neurocognition and
                      Genetics (PING) cohort. Then, we sought to contextualise the
                      findings using (i) age-matched transcriptomics, (ii)
                      gradients of cortical differentiation and (iii) case-control
                      differences of major psychiatric disorders. Higher PRS-SCZ
                      was associated with greater cortical thickness in typically
                      developing children, while surface area and cortical volume
                      showed only subtle associations. Greater cortical thickness
                      was most prominent in areas with heightened gene expression
                      for dendrites and synapses. The pattern of PRS-SCZ
                      associations with cortical thickness reflected functional
                      specialisation in the cortex and was spatially related to
                      cortical abnormalities of patient populations of
                      schizophrenia, bipolar disorder, and major depression.
                      Finally, age interaction models indicated PRS-SCZ effects on
                      cortical thickness were most pronounced between ages 3 and
                      6, suggesting an influence of PRS-SCZ on cortical maturation
                      early in life. Integrating imaging-genetics with multi-scale
                      mapping of cortical organization, our work contributes to an
                      emerging understanding of how risk for schizophrenia and
                      related disorders manifest in early life.},
      cin          = {INM-1 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {5254 - Neuroscientific Data Analytics and AI (POF4-525) /
                      HIBALL - Helmholtz International BigBrain Analytics and
                      Learning Laboratory (HIBALL) (InterLabs-0015)},
      pid          = {G:(DE-HGF)POF4-5254 / G:(DE-HGF)InterLabs-0015},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37881579},
      UT           = {WOS:001098291000001},
      doi          = {10.1016/j.bpsgos.2022.08.003},
      url          = {https://juser.fz-juelich.de/record/911339},
}