%0 Journal Article
%A Hettwer, M. D.
%A Larivière, S.
%A Park, B. Y.
%A van den Heuvel, O. A.
%A Schmaal, L.
%A Andreassen, O. A.
%A Ching, C. R. K.
%A Hoogman, M.
%A Buitelaar, J.
%A van Rooij, D.
%A Veltman, D. J.
%A Stein, D. J.
%A Franke, B.
%A van Erp, T. G. M.
%A van Rooij, D.
%A van den Heuvel, O. A.
%A van Erp, T. G. M.
%A Jahanshad, N.
%A Thompson, P. M.
%A Thomopoulos, S. I.
%A Bethlehem, R. A. I.
%A Bernhardt, B. C.
%A Eickhoff, S. B.
%A Valk, S. L.
%T Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
%J Nature Communications
%V 13
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M FZJ-2022-04652
%P 6851
%D 2022
%X Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 36369423
%U <Go to ISI:>//WOS:000882306500005
%R 10.1038/s41467-022-34367-6
%U https://juser.fz-juelich.de/record/911369