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000911369 1001_ $$0P:(DE-Juel1)187157$$aHettwer, M. D.$$b0$$eCorresponding author
000911369 245__ $$aCoordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
000911369 260__ $$a[London]$$bNature Publishing Group UK$$c2022
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000911369 520__ $$aNeuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.
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000911369 7001_ $$0P:(DE-HGF)0$$aLarivière, S.$$b1
000911369 7001_ $$0P:(DE-HGF)0$$aPark, B. Y.$$b2
000911369 7001_ $$0P:(DE-HGF)0$$avan den Heuvel, O. A.$$b3
000911369 7001_ $$0P:(DE-HGF)0$$aSchmaal, L.$$b4
000911369 7001_ $$0P:(DE-HGF)0$$aAndreassen, O. A.$$b5
000911369 7001_ $$0P:(DE-HGF)0$$aChing, C. R. K.$$b6
000911369 7001_ $$0P:(DE-HGF)0$$aHoogman, M.$$b7
000911369 7001_ $$0P:(DE-HGF)0$$aBuitelaar, J.$$b8
000911369 7001_ $$0P:(DE-HGF)0$$avan Rooij, D.$$b9
000911369 7001_ $$0P:(DE-HGF)0$$aVeltman, D. J.$$b10
000911369 7001_ $$0P:(DE-HGF)0$$aStein, D. J.$$b11
000911369 7001_ $$0P:(DE-HGF)0$$aFranke, B.$$b12
000911369 7001_ $$0P:(DE-HGF)0$$avan Erp, T. G. M.$$b13
000911369 7001_ $$0P:(DE-HGF)0$$avan Rooij, D.$$b14
000911369 7001_ $$0P:(DE-HGF)0$$avan den Heuvel, O. A.$$b15
000911369 7001_ $$0P:(DE-HGF)0$$avan Erp, T. G. M.$$b16
000911369 7001_ $$0P:(DE-HGF)0$$aJahanshad, N.$$b17
000911369 7001_ $$0P:(DE-HGF)0$$aThompson, P. M.$$b18
000911369 7001_ $$0P:(DE-HGF)0$$aThomopoulos, S. I.$$b19
000911369 7001_ $$0P:(DE-HGF)0$$aBethlehem, R. A. I.$$b20
000911369 7001_ $$0P:(DE-HGF)0$$aBernhardt, B. C.$$b21
000911369 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b22
000911369 7001_ $$0P:(DE-Juel1)173843$$aValk, S. L.$$b23
000911369 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-022-34367-6$$gVol. 13, no. 1, p. 6851$$n1$$p6851$$tNature Communications$$v13$$x2041-1723$$y2022
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000911369 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)187157$$a Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig$$b0
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