TY  - JOUR
AU  - Hettwer, M. D.
AU  - Larivière, S.
AU  - Park, B. Y.
AU  - van den Heuvel, O. A.
AU  - Schmaal, L.
AU  - Andreassen, O. A.
AU  - Ching, C. R. K.
AU  - Hoogman, M.
AU  - Buitelaar, J.
AU  - van Rooij, D.
AU  - Veltman, D. J.
AU  - Stein, D. J.
AU  - Franke, B.
AU  - van Erp, T. G. M.
AU  - van Rooij, D.
AU  - van den Heuvel, O. A.
AU  - van Erp, T. G. M.
AU  - Jahanshad, N.
AU  - Thompson, P. M.
AU  - Thomopoulos, S. I.
AU  - Bethlehem, R. A. I.
AU  - Bernhardt, B. C.
AU  - Eickhoff, S. B.
AU  - Valk, S. L.
TI  - Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
JO  - Nature Communications
VL  - 13
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - FZJ-2022-04652
SP  - 6851
PY  - 2022
AB  - Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.
LB  - PUB:(DE-HGF)16
C6  - 36369423
UR  - <Go to ISI:>//WOS:000882306500005
DO  - DOI:10.1038/s41467-022-34367-6
UR  - https://juser.fz-juelich.de/record/911369
ER  -