% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hettwer:911369,
      author       = {Hettwer, M. D. and Larivière, S. and Park, B. Y. and van
                      den Heuvel, O. A. and Schmaal, L. and Andreassen, O. A. and
                      Ching, C. R. K. and Hoogman, M. and Buitelaar, J. and van
                      Rooij, D. and Veltman, D. J. and Stein, D. J. and Franke, B.
                      and van Erp, T. G. M. and van Rooij, D. and van den Heuvel,
                      O. A. and van Erp, T. G. M. and Jahanshad, N. and Thompson,
                      P. M. and Thomopoulos, S. I. and Bethlehem, R. A. I. and
                      Bernhardt, B. C. and Eickhoff, S. B. and Valk, S. L.},
      title        = {{C}oordinated cortical thickness alterations across six
                      neurodevelopmental and psychiatric disorders},
      journal      = {Nature Communications},
      volume       = {13},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2022-04652},
      pages        = {6851},
      year         = {2022},
      abstract     = {Neuropsychiatric disorders are increasingly conceptualized
                      as overlapping spectra sharing multi-level neurobiological
                      alterations. However, whether transdiagnostic cortical
                      alterations covary in a biologically meaningful way is
                      currently unknown. Here, we studied co-alteration networks
                      across six neurodevelopmental and psychiatric disorders,
                      reflecting pathological structural covariance. In 12,024
                      patients and 18,969 controls from the ENIGMA consortium, we
                      observed that co-alteration patterns followed normative
                      connectome organization and were anchored to prefrontal and
                      temporal disease epicenters. Manifold learning revealed
                      frontal-to-temporal and sensory/limbic-to-occipitoparietal
                      transdiagnostic gradients, differentiating shared illness
                      effects on cortical thickness along these axes. The
                      principal gradient aligned with a normative cortical
                      thickness covariance gradient and established a
                      transcriptomic link to cortico-cerebello-thalamic circuits.
                      Moreover, transdiagnostic gradients segregated functional
                      networks involved in basic sensory, attentional/perceptual,
                      and domain-general cognitive processes, and distinguished
                      between regional cytoarchitectonic profiles. Together, our
                      findings indicate that shared illness effects occur in a
                      synchronized fashion and along multiple levels of
                      hierarchical cortical organization.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36369423},
      UT           = {WOS:000882306500005},
      doi          = {10.1038/s41467-022-34367-6},
      url          = {https://juser.fz-juelich.de/record/911369},
}