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| Hauptseite > Publikationsdatenbank > Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders > print |
| Hauptseite > Publikationsdatenbank > Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders > print |
| 001 | 911369 | ||
| 005 | 20230308082006.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-022-34367-6 |2 doi |
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| 037 | _ | _ | |a FZJ-2022-04652 |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Hettwer, M. D. |0 P:(DE-Juel1)187157 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders |
| 260 | _ | _ | |a [London] |c 2022 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization. |
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| 773 | _ | _ | |a 10.1038/s41467-022-34367-6 |g Vol. 13, no. 1, p. 6851 |0 PERI:(DE-600)2553671-0 |n 1 |p 6851 |t Nature Communications |v 13 |y 2022 |x 2041-1723 |
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