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@ARTICLE{Brger:911472,
      author       = {Bürger, Zoé and Müller, Veronika I. and Hoffstaedter,
                      Felix and Habel, Ute and Gur, Ruben C. and Windischberger,
                      Christian and Moser, Ewald and Derntl, Birgit and Kogler,
                      Lydia},
      title        = {{S}tressor-{S}pecific {S}ex {D}ifferences in
                      {A}mygdala-{F}rontal {C}ortex {N}etworks},
      journal      = {SSRN eLibrary},
      issn         = {1556-5068},
      address      = {[S.l.]},
      publisher    = {Social Science Electronic Publ.},
      reportid     = {FZJ-2022-04743},
      year         = {2022},
      abstract     = {Women and men differ in their stress reactivity and stress
                      coping and in the prevalence rates of stress-related
                      disorders. Sex differences also exist in the reaction to
                      different stressors: while women seem more susceptible to
                      social exclusion, men seem to react stronger to achievement
                      stress. Following a model of stress coping, target brain
                      regions were identified including amygdala, dorsolateral
                      prefrontal cortex (dlPFC), ventral anterior cingulate cortex
                      (vACC) and medial prefrontal cortex (mPFC). We investigated
                      sex differences in stress reactivity on a subjective,
                      hormonal, and resting-state functional connectivity (rsFC)
                      level by administering two different stressors to 40 females
                      and 37 males: (1) achievement stress via a modified version
                      of the Montreal Imaging Stress Task, and (2) social
                      exclusion through the Cyberball paradigm. To assess
                      manipulation in amygdala-frontal networks, rs-scans were
                      obtained before and after each stressor. Additionally,
                      cortisol levels and subjective affect were assessed. For
                      social exclusion, amygdala–vACC and amygdala–mPFC rsFC
                      was higher in females than males, with a positive
                      association of amygdala–vACC rsFC with cortisol in
                      females. Further, amygdala–vACC rsFC was higher for social
                      exclusion compared to achievement stress in females. For
                      achievement stress, associations of positive affect with
                      amygdala–mPFC rsFC and anger with amygdala–vACC rsFC
                      were observed. Higher amygdala–vACC rsFC and its positive
                      association with cortisol indicates a higher need for
                      processing and coping with social exclusion in women than
                      men. Higher amygdala–mPFC rsFC, however, indicates
                      feelings of reward and social gain, pointing to positive
                      effects of social affiliation. Thus, for females, feeling
                      socially affiliated might be more fundamental than for
                      males. Contrarily, during achievement stress a different
                      pattern emerged with higher amygdala–mPFC and lower
                      amygdala–vACC rsFC being associated with more negative
                      mood, which might be associated with goal directed
                      behaviour. Thus, our data indicate sex-specific rsFC,
                      cortisol and mood patterns during social exclusion and
                      achievement stress and contribute to a better understanding
                      of sex differences in rsFC due to different stressors.},
      cin          = {INM-7 / INM-10},
      ddc          = {330},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-10-20170113},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.2139/ssrn.4134211},
      url          = {https://juser.fz-juelich.de/record/911472},
}