000911484 001__ 911484 000911484 005__ 20230123101839.0 000911484 037__ $$aFZJ-2022-04753 000911484 1001_ $$0P:(DE-Juel1)177611$$aDrzezga, Alexander$$b0$$ufzj 000911484 245__ $$aPET and SPECT Imaging of Neurodegenerative Diseases 000911484 260__ $$aAmsterdam$$bElsevier$$c2021 000911484 29510 $$aMolecular Imaging: Principles and Practice 000911484 300__ $$a1309-1334 000911484 3367_ $$2ORCID$$aBOOK_CHAPTER 000911484 3367_ $$07$$2EndNote$$aBook Section 000911484 3367_ $$2DRIVER$$abookPart 000911484 3367_ $$2BibTeX$$aINBOOK 000911484 3367_ $$2DataCite$$aOutput Types/Book chapter 000911484 3367_ $$0PUB:(DE-HGF)7$$2PUB:(DE-HGF)$$aContribution to a book$$bcontb$$mcontb$$s1668669151_29672 000911484 500__ $$a 000911484 520__ $$aToday, a number of complementary molecular imaging methods are at our disposal, which can make a relevant contribution to early diagnosis, differential diagnosis, disease monitoring, and follow-up of neurodegenerative diseases. This includes long-established FDG-PET which provides valuable information on location and extent of pathology and has demonstrated great value for early diagnosis, short-term prognosis, and for differential diagnosis of various disorders on the basis of the endophenotype of disease. Imaging of the dopaminergic system has proven value in the workup of movement disorders. More recently introduced, amyloid-PET for the first time allows in vivo diagnostic assessment of a molecular neuropathology, most valuable for verification or exclusion of Alzheimer disease (AD), independent of the symptomatic appearance. Finally, new tracers for tau-PET imaging may allow the assessment of location, extent, and specific type of pathology, which may hold great value for early and differential diagnosis of neurodegeneration in the future. 000911484 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0 000911484 536__ $$0G:(DE-HGF)POF4-5253$$a5253 - Neuroimaging (POF4-525)$$cPOF4-525$$fPOF IV$$x1 000911484 7001_ $$0P:(DE-HGF)0$$aBischof, Gérard$$b1 000911484 7001_ $$0P:(DE-HGF)0$$aGiehl, Kathrin$$b2 000911484 7001_ $$0P:(DE-HGF)0$$aEimeren, Thilo van$$b3 000911484 8564_ $$uhttps://www.researchgate.net/publication/354825733_PET_and_SPECT_Imaging_of_Neurodegenerative_Diseases 000911484 909CO $$ooai:juser.fz-juelich.de:911484$$pVDB 000911484 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177611$$aForschungszentrum Jülich$$b0$$kFZJ 000911484 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0 000911484 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5253$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x1 000911484 9141_ $$y2022 000911484 920__ $$lyes 000911484 9201_ $$0I:(DE-Juel1)INM-2-20090406$$kINM-2$$lMolekulare Organisation des Gehirns$$x0 000911484 980__ $$acontb 000911484 980__ $$aVDB 000911484 980__ $$aI:(DE-Juel1)INM-2-20090406 000911484 980__ $$aUNRESTRICTED