%0 Electronic Article
%A Weihs, Antoine
%A Frenzel, Stefan
%A Bi, Hanwen
%A Schiel, Julian
%A Afshani, Mortaza
%A Bülow, Robin
%A Ewert, Ralf
%A Fietze, Ingo
%A Hoffstaedter, Felix
%A Jahanshad, Neda
%A Khazaie, Habibolah
%A Riemann, Dieter
%A Rostampour, Masoumeh
%A Stubbe, Beate
%A Thomopoulos, Sophia
%A Thompson, Paul
%A Valk, Sofie
%A Völzke, Henry
%A Zarei, Mojtaba
%A Eickhoff, Simon
%A Grabe, Hans
%A Patil, Kaustubh
%A Spiegelhalder, Kai
%A Tahmasian, Masoud
%T Lack of Structural Brain Alterations associated with Insomnia: Findings from the ENIGMA-Sleep working group
%M FZJ-2022-04776
%D 2022
%X Existing neuroimaging studies have reported divergent structural alterations in insomnia. Here, we performed a large-scale coordinated meta-analysis by pooling structural brain measures from 1,085 subjects with and without insomnia symptoms across three international ENIGMA-Sleep cohorts. The influence of insomnia on MRI-based brain morphometry using an insomnia brain score was assessed. We collected case-control data from two sites, as well as population-based data from another site. Within each cohort, we used an ordinary least-squares linear regression to investigate the link between the individual regional cortical thickness and subcortical volumes and the presence of insomnia symptoms. Then, we performed a fixed-effects meta-analysis across cohorts based on the first-level results. For the insomnia brain score, weighted logistic ridge regression was performed on one sample, which separated patients with insomnia disorder from controls to train a model based on the segmentation measurements. Afterward, the insomnia brain scores were validated using the other two samples. The model was used to predict the log-odds of the subjects with insomnia given individual insomnia-related brain atrophy. After adjusting for multiple comparisons, we did not detect any significant associations between insomnia symptoms and cortical or subcortical volumes, nor could we identify a global insomnia-related brain atrophy pattern. The current study found inconsistent brain morphology differences between individuals with and without insomnia across three independent cohorts. Further large-scale cross-sectional and longitudinal studies using both structural and functional neuroimaging data are warranted to decipher the pathophysiology of insomnia at the brain level.
%F PUB:(DE-HGF)25
%9 Preprint
%R 10.21203/rs.3.rs-2203610/v1
%U https://juser.fz-juelich.de/record/911515