TY  - EJOUR
AU  - Weihs, Antoine
AU  - Frenzel, Stefan
AU  - Bi, Hanwen
AU  - Schiel, Julian
AU  - Afshani, Mortaza
AU  - Bülow, Robin
AU  - Ewert, Ralf
AU  - Fietze, Ingo
AU  - Hoffstaedter, Felix
AU  - Jahanshad, Neda
AU  - Khazaie, Habibolah
AU  - Riemann, Dieter
AU  - Rostampour, Masoumeh
AU  - Stubbe, Beate
AU  - Thomopoulos, Sophia
AU  - Thompson, Paul
AU  - Valk, Sofie
AU  - Völzke, Henry
AU  - Zarei, Mojtaba
AU  - Eickhoff, Simon
AU  - Grabe, Hans
AU  - Patil, Kaustubh
AU  - Spiegelhalder, Kai
AU  - Tahmasian, Masoud
TI  - Lack of Structural Brain Alterations associated with Insomnia: Findings from the ENIGMA-Sleep working group
M1  - FZJ-2022-04776
PY  - 2022
AB  - Existing neuroimaging studies have reported divergent structural alterations in insomnia. Here, we performed a large-scale coordinated meta-analysis by pooling structural brain measures from 1,085 subjects with and without insomnia symptoms across three international ENIGMA-Sleep cohorts. The influence of insomnia on MRI-based brain morphometry using an insomnia brain score was assessed. We collected case-control data from two sites, as well as population-based data from another site. Within each cohort, we used an ordinary least-squares linear regression to investigate the link between the individual regional cortical thickness and subcortical volumes and the presence of insomnia symptoms. Then, we performed a fixed-effects meta-analysis across cohorts based on the first-level results. For the insomnia brain score, weighted logistic ridge regression was performed on one sample, which separated patients with insomnia disorder from controls to train a model based on the segmentation measurements. Afterward, the insomnia brain scores were validated using the other two samples. The model was used to predict the log-odds of the subjects with insomnia given individual insomnia-related brain atrophy. After adjusting for multiple comparisons, we did not detect any significant associations between insomnia symptoms and cortical or subcortical volumes, nor could we identify a global insomnia-related brain atrophy pattern. The current study found inconsistent brain morphology differences between individuals with and without insomnia across three independent cohorts. Further large-scale cross-sectional and longitudinal studies using both structural and functional neuroimaging data are warranted to decipher the pathophysiology of insomnia at the brain level.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.21203/rs.3.rs-2203610/v1
UR  - https://juser.fz-juelich.de/record/911515
ER  -