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000911611 0247_ $$2doi$$a10.1016/j.biopsych.2022.04.022
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000911611 1001_ $$0P:(DE-HGF)0$$aWalton, Esther$$b0
000911611 245__ $$aBrain Structure in Acutely Underweight and Partially Weight-Restored Individuals With Anorexia Nervosa: A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
000911611 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2022
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000911611 520__ $$aBACKGROUND: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood.While several studies report substantial deficits in gray matter volume and cortical thickness in acutely underweightpatients, others find no differences, or even increases in patients compared with healthy control subjects. Recentweight regain before scanning may explain some of this heterogeneity. To clarify the extent, magnitude, and de-pendencies of gray matter changes in AN, we conducted a prospective, coordinated meta-analysis of multicenterneuroimaging data.METHODS: We analyzed T1-weighted structural magnetic resonance imaging scans assessed with standardizedmethods from 685 female patients with AN and 963 female healthy control subjects across 22 sites worldwide. Inaddition to a case-control comparison, we conducted a 3-group analysis comparing healthy control subjects withacutely underweight AN patients (n = 466) and partially weight-restored patients in treatment (n = 251).RESULTS: In AN, reductions in cortical thickness, subcortical volumes, and, to a lesser extent, cortical surface areawere sizable (Cohen’s d up to 0.95), widespread, and colocalized with hub regions. Highlighting the effects of un-dernutrition, these deficits were associated with lower body mass index in the AN sample and were less pronouncedin partially weight-restored patients.CONCLUSIONS: The effect sizes observed for cortical thickness deficits in acute AN are the largest of any psychiatricdisorder investigated in the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium to date.These results confirm the importance of considering weight loss and renutrition in biomedical research on AN andunderscore the importance of treatment engagement to prevent potentially long-lasting structural brain changes inthis population.
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000911611 7001_ $$0P:(DE-HGF)0$$aBernardoni, Fabio$$b1
000911611 7001_ $$0P:(DE-HGF)0$$aBatury, Victoria-Luise$$b2
000911611 7001_ $$0P:(DE-HGF)0$$aBahnsen, Klaas$$b3
000911611 7001_ $$0P:(DE-HGF)0$$aLarivière, Sara$$b4
000911611 7001_ $$0P:(DE-HGF)0$$aAbbate-Daga, Giovanni$$b5
000911611 7001_ $$0P:(DE-HGF)0$$aAndres-Perpiña, Susana$$b6
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000911611 7001_ $$0P:(DE-HGF)0$$aBischoff-Grethe, Amanda$$b8
000911611 7001_ $$0P:(DE-HGF)0$$aBrooks, Samantha J.$$b9
000911611 7001_ $$0P:(DE-HGF)0$$aCampbell, Iain C.$$b10
000911611 7001_ $$0P:(DE-HGF)0$$aCascino, Giammarco$$b11
000911611 7001_ $$0P:(DE-HGF)0$$aCastro-Fornieles, Josefina$$b12
000911611 7001_ $$0P:(DE-HGF)0$$aCollantoni, Enrico$$b13
000911611 7001_ $$0P:(DE-HGF)0$$aD’Agata, Federico$$b14
000911611 7001_ $$0P:(DE-HGF)0$$aDahmen, Brigitte$$b15
000911611 7001_ $$0P:(DE-HGF)0$$aDanner, Unna N.$$b16
000911611 7001_ $$0P:(DE-HGF)0$$aFavaro, Angela$$b17
000911611 7001_ $$0P:(DE-HGF)0$$aFeusner, Jamie D.$$b18
000911611 7001_ $$0P:(DE-HGF)0$$aFrank, Guido K. W.$$b19
000911611 7001_ $$0P:(DE-HGF)0$$aFriederich, Hans-Christoph$$b20
000911611 7001_ $$0P:(DE-HGF)0$$aGraner, John L.$$b21
000911611 7001_ $$0P:(DE-HGF)0$$aHerpertz-Dahlmann, Beate$$b22
000911611 7001_ $$0P:(DE-HGF)0$$aHess, Andreas$$b23
000911611 7001_ $$0P:(DE-HGF)0$$aHorndasch, Stefanie$$b24
000911611 7001_ $$0P:(DE-HGF)0$$aKaplan, Allan S.$$b25
000911611 7001_ $$0P:(DE-HGF)0$$aKaufmann, Lisa-Katrin$$b26
000911611 7001_ $$0P:(DE-HGF)0$$aKaye, Walter H.$$b27
000911611 7001_ $$0P:(DE-HGF)0$$aKhalsa, Sahib S.$$b28
000911611 7001_ $$0P:(DE-HGF)0$$aLaBar, Kevin S.$$b29
000911611 7001_ $$0P:(DE-HGF)0$$aLavagnino, Luca$$b30
000911611 7001_ $$0P:(DE-HGF)0$$aLazaro, Luisa$$b31
000911611 7001_ $$0P:(DE-HGF)0$$aManara, Renzo$$b32
000911611 7001_ $$0P:(DE-HGF)0$$aMiles, Amy E.$$b33
000911611 7001_ $$0P:(DE-HGF)0$$aMilos, Gabriella F.$$b34
000911611 7001_ $$0P:(DE-HGF)0$$aMonteleone, Alessio Maria$$b35
000911611 7001_ $$0P:(DE-HGF)0$$aMonteleone, Palmiero$$b36
000911611 7001_ $$0P:(DE-HGF)0$$aMwangi, Benson$$b37
000911611 7001_ $$0P:(DE-HGF)0$$aO’Daly, Owen$$b38
000911611 7001_ $$0P:(DE-HGF)0$$aPariente, Jose$$b39
000911611 7001_ $$0P:(DE-HGF)0$$aRoesch, Julie$$b40
000911611 7001_ $$0P:(DE-HGF)0$$aSchmidt, Ulrike H.$$b41
000911611 7001_ $$0P:(DE-HGF)0$$aSeitz, Jochen$$b42
000911611 7001_ $$0P:(DE-HGF)0$$aShott, Megan E.$$b43
000911611 7001_ $$0P:(DE-HGF)0$$aSimon, Joe J.$$b44
000911611 7001_ $$0P:(DE-HGF)0$$aSmeets, Paul A. M.$$b45
000911611 7001_ $$0P:(DE-HGF)0$$aTamnes, Christian K.$$b46
000911611 7001_ $$0P:(DE-HGF)0$$aTenconi, Elena$$b47
000911611 7001_ $$0P:(DE-HGF)0$$aThomopoulos, Sophia I.$$b48
000911611 7001_ $$0P:(DE-HGF)0$$aVoineskos, Aristotle N.$$b49
000911611 7001_ $$0P:(DE-HGF)0$$avan Elburg, Annemarie A.$$b50
000911611 7001_ $$0P:(DE-Juel1)177845$$avon Polier, Georg G.$$b51
000911611 7001_ $$0P:(DE-HGF)0$$aWierenga, Christina E.$$b52
000911611 7001_ $$0P:(DE-HGF)0$$aZucker, Nancy L.$$b53
000911611 7001_ $$0P:(DE-HGF)0$$aJahanshad, Neda$$b54
000911611 7001_ $$0P:(DE-HGF)0$$aKing, Joseph A.$$b55
000911611 7001_ $$0P:(DE-HGF)0$$aThompson, Paul M.$$b56
000911611 7001_ $$0P:(DE-HGF)0$$aBerner, Laura A.$$b57
000911611 7001_ $$0P:(DE-HGF)0$$aEhrlich, Stefan$$b58$$eCorresponding author
000911611 773__ $$0PERI:(DE-600)1499907-9$$a10.1016/j.biopsych.2022.04.022$$gVol. 92, no. 9, p. 730 - 738$$n9$$p730 - 738$$tBiological psychiatry$$v92$$x0006-3223$$y2022
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