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@ARTICLE{Walton:911611,
      author       = {Walton, Esther and Bernardoni, Fabio and Batury,
                      Victoria-Luise and Bahnsen, Klaas and Larivière, Sara and
                      Abbate-Daga, Giovanni and Andres-Perpiña, Susana and Bang,
                      Lasse and Bischoff-Grethe, Amanda and Brooks, Samantha J.
                      and Campbell, Iain C. and Cascino, Giammarco and
                      Castro-Fornieles, Josefina and Collantoni, Enrico and
                      D’Agata, Federico and Dahmen, Brigitte and Danner, Unna N.
                      and Favaro, Angela and Feusner, Jamie D. and Frank, Guido K.
                      W. and Friederich, Hans-Christoph and Graner, John L. and
                      Herpertz-Dahlmann, Beate and Hess, Andreas and Horndasch,
                      Stefanie and Kaplan, Allan S. and Kaufmann, Lisa-Katrin and
                      Kaye, Walter H. and Khalsa, Sahib S. and LaBar, Kevin S. and
                      Lavagnino, Luca and Lazaro, Luisa and Manara, Renzo and
                      Miles, Amy E. and Milos, Gabriella F. and Monteleone,
                      Alessio Maria and Monteleone, Palmiero and Mwangi, Benson
                      and O’Daly, Owen and Pariente, Jose and Roesch, Julie and
                      Schmidt, Ulrike H. and Seitz, Jochen and Shott, Megan E. and
                      Simon, Joe J. and Smeets, Paul A. M. and Tamnes, Christian
                      K. and Tenconi, Elena and Thomopoulos, Sophia I. and
                      Voineskos, Aristotle N. and van Elburg, Annemarie A. and von
                      Polier, Georg G. and Wierenga, Christina E. and Zucker,
                      Nancy L. and Jahanshad, Neda and King, Joseph A. and
                      Thompson, Paul M. and Berner, Laura A. and Ehrlich, Stefan},
      title        = {{B}rain {S}tructure in {A}cutely {U}nderweight and
                      {P}artially {W}eight-{R}estored {I}ndividuals {W}ith
                      {A}norexia {N}ervosa: {A} {C}oordinated {A}nalysis by the
                      {ENIGMA} {E}ating {D}isorders {W}orking {G}roup},
      journal      = {Biological psychiatry},
      volume       = {92},
      number       = {9},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2022-04870},
      pages        = {730 - 738},
      year         = {2022},
      abstract     = {BACKGROUND: The pattern of structural brain abnormalities
                      in anorexia nervosa (AN) is still not well understood.While
                      several studies report substantial deficits in gray matter
                      volume and cortical thickness in acutely
                      underweightpatients, others find no differences, or even
                      increases in patients compared with healthy control
                      subjects. Recentweight regain before scanning may explain
                      some of this heterogeneity. To clarify the extent,
                      magnitude, and de-pendencies of gray matter changes in AN,
                      we conducted a prospective, coordinated meta-analysis of
                      multicenterneuroimaging data.METHODS: We analyzed
                      T1-weighted structural magnetic resonance imaging scans
                      assessed with standardizedmethods from 685 female patients
                      with AN and 963 female healthy control subjects across 22
                      sites worldwide. Inaddition to a case-control comparison, we
                      conducted a 3-group analysis comparing healthy control
                      subjects withacutely underweight AN patients (n = 466) and
                      partially weight-restored patients in treatment (n =
                      251).RESULTS: In AN, reductions in cortical thickness,
                      subcortical volumes, and, to a lesser extent, cortical
                      surface areawere sizable (Cohen’s d up to 0.95),
                      widespread, and colocalized with hub regions. Highlighting
                      the effects of un-dernutrition, these deficits were
                      associated with lower body mass index in the AN sample and
                      were less pronouncedin partially weight-restored
                      patients.CONCLUSIONS: The effect sizes observed for cortical
                      thickness deficits in acute AN are the largest of any
                      psychiatricdisorder investigated in the ENIGMA (Enhancing
                      Neuro Imaging Genetics through Meta Analysis) Consortium to
                      date.These results confirm the importance of considering
                      weight loss and renutrition in biomedical research on AN
                      andunderscore the importance of treatment engagement to
                      prevent potentially long-lasting structural brain changes
                      inthis population.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36031441},
      UT           = {WOS:000878185900008},
      doi          = {10.1016/j.biopsych.2022.04.022},
      url          = {https://juser.fz-juelich.de/record/911611},
}