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000911654 1001_ $$0P:(DE-Juel1)131988$$aWeiergräber, Oliver H.$$b0$$eCorresponding author
000911654 245__ $$aStructure and Dynamics of Human Chemokine CCL16—Implications for Biological Activity
000911654 260__ $$aBasel$$bMDPI$$c2022
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000911654 520__ $$aHuman C-C motif ligand 16 (CCL16) is a chemokine that is distinguished by a large cleavable C-terminal extension of unknown significance. Conflicting data have been reported concerning its tissue distribution and modulation of expression, rendering the biological function of CCL16 enigmatic. Here, we report an integrated approach to the characterisation of this chemokine, including a re-assessment of its expression characteristics as well as a biophysical investigation with respect to its structure and dynamics. Our data indicate that CCL16 is chiefly synthesised by hepatocytes, without an appreciable response to mediators of inflammation, and circulates in the blood as a full-length protein. While the crystal structure of CCL16 confirms the presence of a canonical chemokine domain, molecular dynamics simulations support the view that the C-terminal extension impairs the accessibility of the glycosaminoglycan binding sites and may thus serve as an intrinsic modulator of biological activity.
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000911654 7001_ $$0P:(DE-Juel1)165744$$aPetrović, Dušan$$b1
000911654 7001_ $$00000-0001-8206-6377$$aKislat, Andreas$$b2
000911654 7001_ $$0P:(DE-Juel1)141687$$aPattky, Martin$$b3
000911654 7001_ $$0P:(DE-Juel1)138746$$aFabig, Judith$$b4
000911654 7001_ $$0P:(DE-Juel1)131950$$aBatra-Safferling, Renu$$b5
000911654 7001_ $$00000-0002-2101-5012$$aSchulte am Esch, Jan$$b6
000911654 7001_ $$0P:(DE-Juel1)132005$$aHänel, Karen$$b7
000911654 7001_ $$aHuhn, Carolin$$b8
000911654 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b9
000911654 7001_ $$0P:(DE-HGF)0$$aHomey, Bernhard$$b10
000911654 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b11$$eCorresponding author
000911654 773__ $$0PERI:(DE-600)2701262-1$$a10.3390/biom12111588$$gVol. 12, no. 11, p. 1588 -$$n11$$p1588 -$$tBiomolecules$$v12$$x2218-273X$$y2022
000911654 8564_ $$uhttps://juser.fz-juelich.de/record/911654/files/biomolecules-12-01588-v2.pdf$$yOpenAccess
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