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000911707 1001_ $$0P:(DE-HGF)0$$aBayrak, Şeyma$$b0$$eCorresponding author
000911707 245__ $$aHeritability of hippocampal functional and microstructural organisation
000911707 260__ $$aOrlando, Fla.$$bAcademic Press$$c2022
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000911707 520__ $$aThe hippocampus is a uniquely infolded allocortical structure in the medial temporal lobe that consists of the microstructurally and functionally distinct subregions: subiculum, cornu ammonis, and dentate gyrus. The hippocampus is a remarkably plastic region that is implicated in learning and memory. At the same time it has been shown that hippocampal subregion volumes are heritable, and that genetic expression varies along a posterior to anterior axis. Here, we studied how a heritable, stable, hippocampal organisation may support its flexible function in healthy adults. Leveraging the twin set-up of the Human Connectome Project with multimodal neuroimaging, we observed that the functional connectivity between hippocampus and cortex was heritable and that microstructure of the hippocampus genetically correlated with cortical microstructure. Moreover, both functional and microstructural organisation could be consistently captured by anterior-to-posterior and medial-to-lateral axes across individuals. However, heritability of functional, relative to microstructural, organisation was found reduced, suggesting individual variation in functional organisation may be explained by experience-driven factors. Last, we demonstrate that structure and function couple along an inherited macroscale organisation, suggesting an interplay of stability and plasticity within the hippocampus. Our study provides new insights on the heritability of the hippocampal of the structure and function within the hippocampal organisation.
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000911707 7001_ $$0P:(DE-HGF)0$$ade Wael, Reinder Vos$$b1
000911707 7001_ $$0P:(DE-HGF)0$$aSchaare, H. Lina$$b2
000911707 7001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike D.$$b3$$ufzj
000911707 7001_ $$0P:(DE-HGF)0$$aCaldairou, Benoit$$b4
000911707 7001_ $$0P:(DE-HGF)0$$aBernasconi, Andrea$$b5
000911707 7001_ $$0P:(DE-HGF)0$$aBernasconi, Neda$$b6
000911707 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C.$$b7
000911707 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b8$$eCorresponding author$$ufzj
000911707 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2022.119656$$gVol. 264, p. 119656 -$$p119656 -$$tNeuroImage$$v264$$x1053-8119$$y2022
000911707 8564_ $$uhttps://juser.fz-juelich.de/record/911707/files/1-s2.0-S1053811922007716-main.pdf$$yOpenAccess
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