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000911708 0247_ $$2doi$$a10.1038/s42003-022-03963-z
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000911708 1001_ $$0P:(DE-HGF)0$$aPark, Bo-yong$$b0$$eCorresponding author
000911708 245__ $$aMultiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
000911708 260__ $$aLondon$$bSpringer Nature$$c2022
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000911708 520__ $$aIt is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we identified a cortex-wide dimension of morphological changes that described a sensory-fugal pattern, with paralimbic regions showing the most consistent alterations across conditions. The shared disease dimension was closely related to cortical gradients of microstructure as well as neurotransmitter axes, specifically cortex-wide variations in serotonin and dopamine. Multiple sensitivity analyses confirmed robustness with respect to slight variations in analytical choices. Our findings embed shared effects of common psychiatric conditions on brain structure in multiple scales of brain organization, and may provide insights into neural mechanisms of transdiagnostic vulnerability
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000911708 7001_ $$0P:(DE-HGF)0$$aLarivière, Sara$$b1
000911708 7001_ $$0P:(DE-HGF)0$$aKebets, Valeria$$b2
000911708 7001_ $$0P:(DE-Juel1)187157$$aHettwer, Meike D.$$b3
000911708 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b4
000911708 7001_ $$0P:(DE-HGF)0$$avan Rooij, Daan$$b5
000911708 7001_ $$0P:(DE-HGF)0$$aBuitelaar, Jan$$b6
000911708 7001_ $$0P:(DE-HGF)0$$aFranke, Barbara$$b7
000911708 7001_ $$0P:(DE-HGF)0$$aHoogman, Martine$$b8
000911708 7001_ $$0P:(DE-HGF)0$$aSchmaal, Lianne$$b9
000911708 7001_ $$0P:(DE-HGF)0$$aVeltman, Dick J.$$b10
000911708 7001_ $$0P:(DE-HGF)0$$avan den Heuvel, Odile A.$$b11
000911708 7001_ $$0P:(DE-HGF)0$$aStein, Dan J.$$b12
000911708 7001_ $$0P:(DE-HGF)0$$aAndreassen, Ole A.$$b13
000911708 7001_ $$0P:(DE-HGF)0$$aChing, Christopher R. K.$$b14
000911708 7001_ $$0P:(DE-HGF)0$$aTurner, Jessica A.$$b15
000911708 7001_ $$0P:(DE-HGF)0$$avan Erp, Theo G. M.$$b16
000911708 7001_ $$0P:(DE-HGF)0$$aEvans, Alan C.$$b17
000911708 7001_ $$0P:(DE-HGF)0$$aDagher, Alain$$b18
000911708 7001_ $$0P:(DE-HGF)0$$aThomopoulos, Sophia I.$$b19
000911708 7001_ $$0P:(DE-HGF)0$$aThompson, Paul M.$$b20
000911708 7001_ $$0P:(DE-Juel1)173843$$aValk, Sofie L.$$b21
000911708 7001_ $$0P:(DE-HGF)0$$aKirschner, Matthias$$b22
000911708 7001_ $$0P:(DE-HGF)0$$aBernhardt, Boris C.$$b23
000911708 773__ $$0PERI:(DE-600)2919698-X$$a10.1038/s42003-022-03963-z$$gVol. 5, no. 1, p. 1024$$n1$$p1024$$tCommunications biology$$v5$$x2399-3642$$y2022
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