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@ARTICLE{Park:911708,
      author       = {Park, Bo-yong and Larivière, Sara and Kebets, Valeria and
                      Hettwer, Meike D. and Paquola, Casey and van Rooij, Daan and
                      Buitelaar, Jan and Franke, Barbara and Hoogman, Martine and
                      Schmaal, Lianne and Veltman, Dick J. and van den Heuvel,
                      Odile A. and Stein, Dan J. and Andreassen, Ole A. and Ching,
                      Christopher R. K. and Turner, Jessica A. and van Erp, Theo
                      G. M. and Evans, Alan C. and Dagher, Alain and Thomopoulos,
                      Sophia I. and Thompson, Paul M. and Valk, Sofie L. and
                      Kirschner, Matthias and Bernhardt, Boris C.},
      title        = {{M}ultiscale neural gradients reflect transdiagnostic
                      effects of major psychiatric conditions on cortical
                      morphology},
      journal      = {Communications biology},
      volume       = {5},
      number       = {1},
      issn         = {2399-3642},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2022-04960},
      pages        = {1024},
      year         = {2022},
      abstract     = {It is increasingly recognized that multiple psychiatric
                      conditions are underpinned by shared neural pathways,
                      affecting similar brain systems. Here, we carried out a
                      multiscale neural contextualization of shared alterations of
                      cortical morphology across six major psychiatric conditions
                      (autism spectrum disorder, attention deficit/hyperactivity
                      disorder, major depression disorder, obsessive-compulsive
                      disorder, bipolar disorder, and schizophrenia). Our
                      framework cross-referenced shared morphological anomalies
                      with respect to cortical myeloarchitecture and
                      cytoarchitecture, as well as connectome and neurotransmitter
                      organization. Pooling disease-related effects on MRI-based
                      cortical thickness measures across six ENIGMA working
                      groups, including a total of 28,546 participants (12,876
                      patients and 15,670 controls), we identified a cortex-wide
                      dimension of morphological changes that described a
                      sensory-fugal pattern, with paralimbic regions showing the
                      most consistent alterations across conditions. The shared
                      disease dimension was closely related to cortical gradients
                      of microstructure as well as neurotransmitter axes,
                      specifically cortex-wide variations in serotonin and
                      dopamine. Multiple sensitivity analyses confirmed robustness
                      with respect to slight variations in analytical choices. Our
                      findings embed shared effects of common psychiatric
                      conditions on brain structure in multiple scales of brain
                      organization, and may provide insights into neural
                      mechanisms of transdiagnostic vulnerability},
      cin          = {INM-7 / INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / HIBALL - Helmholtz
                      International BigBrain Analytics and Learning Laboratory
                      (HIBALL) (InterLabs-0015)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)InterLabs-0015},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36168040},
      UT           = {WOS:000860702800005},
      doi          = {10.1038/s42003-022-03963-z},
      url          = {https://juser.fz-juelich.de/record/911708},
}