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@INPROCEEDINGS{Daugherty:911989,
      author       = {Daugherty, Ana M. and Saifullah, Samaah and Augustinack,
                      Jean and Amunts, Katrin and Bakker, Arnold and Berron, David
                      and Brown, Thackery and Burggren, Alison and Chetelat, Gael
                      and Florès, Robin de and Ding, Song-Lin and Insausti,
                      Ricardo and Kedo, Olga and Joie, Renaud La and Malykhin,
                      Nikolai and Martinez, Anjelica and Mueller, Susanne and
                      Olsen, Rosanna and Palombo, Daniela and Raz, Naftali and
                      Stark, Craig and Wang, Lei and Wisse, Laura and Yushkevich,
                      Paul and Carr, Valerie},
      title        = {{H}ippocampal {S}ubfields {G}roup progress update:
                      {C}onsensus protocol to segment subfields within the
                      hippocampal body on high-resolution in vivo {MRI}},
      reportid     = {FZJ-2022-05219},
      year         = {2022},
      abstract     = {Hippocampal subfields are differentially sensitive in
                      development, aging, and neurodegenerative disease.
                      High-resolution imaging techniques have accelerated clinical
                      research of hippocampal subfields; however, substantial
                      differences in protocols impede comparisons in the
                      literature across laboratories. The Hippocampal Subfields
                      Group (HSG) is an international organization seeking to
                      address this issue by developing a histologically-valid,
                      reliable, and freely available segmentation protocol for
                      high-resolution T2-weighted 3T MRI
                      (http://www.hippocampalsubfields.com). This progress update
                      presents the consensus draft protocol for segmenting
                      subfields within the hippocampal body. The segmentation
                      protocol is based on a novel histological reference data set
                      labeled by multiple expert neuroanatomists. Two naïve
                      raters demonstrated feasibility on an MRI dataset including
                      brains from children and adults, and all subfield volume
                      measurements had good reliability. Twenty-six labs with
                      reported 4 years or more experience segmenting hippocampal
                      subfields in healthy lifespan and patient populations
                      participated in an online survey, which included detailed
                      protocol information, feasibility testing, demonstration
                      videos, example segmentations, and labeled histology. Due to
                      the complexity of the internal anatomy, two approaches for
                      segmenting the boundary between cornu ammonis (CA) 3 and
                      dentate gyrus subfields were presented, and the majority
                      approved a geometric heuristic-based protocol over one that
                      referenced the endfolial pathway anatomy: $58\%$ geometric,
                      $23\%$ endfolial, and with $19\%$ expressing no opinion.
                      Labs rated each internal boundary definition for clarity and
                      agreement with the protocol on a scale 1 (low) to 9 (high).
                      All definitions were rated with high clarity (M = 8.42 –
                      8.65) and reached consensus agreement (binomial ps < 0.01).
                      The geometric heuristic protocol includes labels for the
                      internal boundaries between subiculum, each CA field, and
                      dentate gyrus, which when combined with the external
                      boundaries that previously reached consensus, labels
                      subfield volumes throughout the hippocampal body. We are now
                      conducting a formal reliability test of the hippocampal body
                      protocol with a group of expert and novice raters who are
                      naïve to the protocol. With confirmation of reliability, we
                      will disseminate the validated harmonized segmentation
                      protocol and resources for automated segmentation. The
                      harmonized protocol will significantly facilitate
                      cross-study comparisons and provide increased insight into
                      the structure and function of hippocampal subfields across
                      the lifespan and in disease.},
      month         = {Nov},
      date          = {2022-11-12},
      organization  = {Society of Neuroscience (SfN), San
                       Diego (USA), 12 Nov 2022 - 16 Nov 2022},
      subtyp        = {Other},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/911989},
}