TY  - JOUR
AU  - Maity, Debabrata
AU  - Oh, Yujeong
AU  - Gremer, Lothar
AU  - Hoyer, Wolfgang
AU  - Magzoub, Mazin
AU  - Hamilton, Andrew D
TI  - Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
JO  - Chemistry - a European journal
VL  - 28
IS  - 38
SN  - 0947-6539
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2022-05395
SP  - na/na
PY  - 2022
AB  - Invited for the cover of this issue is the group of Prof. Hamilton at New York University. The image depicts how cucurbit[7]uril inhibits islet amyloid polypeptide self-assembly that rescues rat insulinoma cells (a pancreatic β-cell model) from assembly-associated cytotoxicity. Read the full text of the article at 10.1002/chem.202200456.
KW  - Amyloid
KW  - Animals
KW  - Bridged-Ring Compounds: pharmacology
KW  - Heterocyclic Compounds, 2-Ring
KW  - Humans
KW  - Imidazoles: pharmacology
KW  - Imidazolidines
KW  - Insulin-Secreting Cells
KW  - Islet Amyloid Polypeptide
KW  - Macrocyclic Compounds
KW  - Rats
KW  - Amyloid (NLM Chemicals)
KW  - Bridged-Ring Compounds (NLM Chemicals)
KW  - Heterocyclic Compounds, 2-Ring (NLM Chemicals)
KW  - Imidazoles (NLM Chemicals)
KW  - Imidazolidines (NLM Chemicals)
KW  - Islet Amyloid Polypeptide (NLM Chemicals)
KW  - Macrocyclic Compounds (NLM Chemicals)
KW  - cucurbit(7)uril (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35701098
UR  - <Go to ISI:>//WOS:000810702900001
DO  - DOI:10.1002/chem.202201698
UR  - https://juser.fz-juelich.de/record/912179
ER  -