TY  - JOUR
AU  - Nikolaev, K. G.
AU  - Ermakov, S. S.
AU  - Ermolenko, Yu. E.
AU  - Navolotskaya, D. V.
AU  - Offenhäusser, A.
AU  - Mourzina, Youlia
TI  - Horseradish Peroxidase-Based Biosensors with Different Nanotransducers for the Determination of Hydrogen Peroxide
JO  - Journal of analytical chemistry
VL  - 76
IS  - 4
SN  - 1061-9348
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - FZJ-2022-05584
SP  - 510 - 517
PY  - 2021
AB  - We studied methods of the in situ synthesis of gold nanostructures on the electrode surface and of the directed electrochemical synthesis of nanodendrites to create biosensors based on horseradish peroxidase. The effect of nanostructuring of the transducer surface and its subsequent modification on the electroanalytical characteristics of sensors for the determination of hydrogen peroxide was studied. The use of these methods can significantly improve the performance characteristics of the biosensors, such as the sensitivity coefficient, limit of detection, and stability in the range of micromolar and submicromolar concentrations of hydrogen peroxide. The electrodes modified by the in situ synthesis of nanostructures with subsequent treatment with Meerwein’s reagent, as well as ultramicroelectrodes prepared by directional electrochemical synthesis, show low limits of detection for hydrogen peroxide, 0.2 and 0.08 µM, and high sensitivity coefficients, 0.71 and 0.84 A M–1 cm–2, respectively.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000640197200011
DO  - DOI:10.1134/S1061934821040080
UR  - https://juser.fz-juelich.de/record/912399
ER  -