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000912509 0247_ $$2doi$$a10.1161/STROKEAHA.121.038455
000912509 0247_ $$2ISSN$$a0039-2499
000912509 0247_ $$2ISSN$$a1524-4628
000912509 0247_ $$2Handle$$a2128/33069
000912509 0247_ $$2pmid$$a35521958
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000912509 1001_ $$00000-0002-7630-7880$$aKuramatsu, Joji B.$$b0$$eCorresponding author
000912509 245__ $$aAssociation of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis
000912509 260__ $$aPhiladelphia, Pa.$$bLippincott Williams & Wilkins$$c2022
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000912509 520__ $$aBackground:In patients with intracerebral hemorrhage (ICH), the presence of intraventricular hemorrhage constitutes a promising therapeutic target. Intraventricular fibrinolysis (IVF) reduces mortality, yet impact on functional disability remains unclear. Thus, we aimed to determine the influence of IVF on functional outcomes.Methods:This individual participant data meta-analysis pooled 1501 patients from 2 randomized trials and 7 observational studies enrolled during 2004 to 2015. We compared IVF versus standard of care (including placebo) in patients treated with external ventricular drainage due to acute hydrocephalus caused by ICH with intraventricular hemorrhage. The primary outcome was functional disability evaluated by the modified Rankin Scale (mRS; range: 0–6, lower scores indicating less disability) at 6 months, dichotomized into mRS score: 0 to 3 versus mRS: 4 to 6. Secondary outcomes included ordinal-shift analysis, all-cause mortality, and intracranial adverse events. Confounding and bias were adjusted by random effects and doubly robust models to calculate odds ratios and absolute treatment effects (ATE).
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000912509 7001_ $$00000-0001-6020-8290$$aGerner, Stefan T.$$b1
000912509 7001_ $$00000-0003-4548-7353$$aZiai, Wendy$$b2
000912509 7001_ $$0P:(DE-HGF)0$$aBardutzky, Jürgen$$b3
000912509 7001_ $$00000-0003-0014-3389$$aSembill, Jochen A.$$b4
000912509 7001_ $$00000-0002-1679-9553$$aSprügel, Maximilian I.$$b5
000912509 7001_ $$00000-0003-0826-4089$$aMrochen, Anne$$b6
000912509 7001_ $$0P:(DE-HGF)0$$aKölbl, Kathrin$$b7
000912509 7001_ $$00000-0002-6505-3037$$aRam, Malathi$$b8
000912509 7001_ $$0P:(DE-HGF)0$$aAvadhani, Radhika$$b9
000912509 7001_ $$00000-0002-6407-0302$$aFalcone, Guido J.$$b10
000912509 7001_ $$00000-0002-1936-3173$$aSelim, Magdy H.$$b11
000912509 7001_ $$00000-0002-8521-0036$$aLioutas, Vasileios-Arsenios$$b12
000912509 7001_ $$00000-0001-6520-3720$$aEndres, Matthias$$b13
000912509 7001_ $$00000-0002-1665-2666$$aZweynert, Sarah$$b14
000912509 7001_ $$00000-0003-4350-392X$$aVajkoczy, Peter$$b15
000912509 7001_ $$00000-0002-5473-8671$$aRingleb, Peter A.$$b16
000912509 7001_ $$00000-0003-2978-4972$$aPurrucker, Jan C.$$b17
000912509 7001_ $$00000-0002-9570-593X$$aVolkmann, Jens$$b18
000912509 7001_ $$00000-0003-3759-356X$$aNeugebauer, Hermann$$b19
000912509 7001_ $$00000-0002-9271-198X$$aErbguth, Frank$$b20
000912509 7001_ $$00000-0002-8517-0353$$aSchellinger, Peter D.$$b21
000912509 7001_ $$0P:(DE-HGF)0$$aKnappe, Ulrich J.$$b22
000912509 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b23$$ufzj
000912509 7001_ $$0P:(DE-HGF)0$$aDohmen, Christian$$b24
000912509 7001_ $$0P:(DE-HGF)0$$aMinnerup, Jens$$b25
000912509 7001_ $$00000-0001-9639-1429$$aReichmann, Heinz$$b26
000912509 7001_ $$00000-0002-9641-0922$$aSchneider, Hauke$$b27
000912509 7001_ $$00000-0002-8088-9991$$aRöther, Joachim$$b28
000912509 7001_ $$00000-0001-7019-6975$$aReimann, Gernot$$b29
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000912509 7001_ $$00000-0001-8944-8239$$aBäzner, Hansjörg$$b31
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000912509 7001_ $$00000-0002-0206-5380$$aMichalski, Dominik$$b33
000912509 7001_ $$00000-0003-2101-4105$$aWitte, Otto W.$$b34
000912509 7001_ $$00000-0002-2394-3947$$aGünther, Albrecht$$b35
000912509 7001_ $$00000-0001-9140-653X$$aHamann, Gerhard F.$$b36
000912509 7001_ $$00000-0002-3935-0003$$aLücking, Hannes$$b37
000912509 7001_ $$00000-0002-3076-3231$$aDörfler, Arnd$$b38
000912509 7001_ $$0P:(DE-HGF)0$$aIshfaq, Muhammad Fawad$$b39
000912509 7001_ $$00000-0002-0825-3008$$aChang, Jason J.$$b40
000912509 7001_ $$00000-0002-7355-4915$$aTestai, Fernando D.$$b41
000912509 7001_ $$00000-0002-2466-7155$$aWoo, Daniel$$b42
000912509 7001_ $$00000-0001-8871-1023$$aAlexandrov, Andrei V.$$b43
000912509 7001_ $$0P:(DE-HGF)0$$aStaykov, Dimitre$$b44
000912509 7001_ $$00000-0002-4699-0922$$aGoyal, Nitin$$b45
000912509 7001_ $$00000-0002-0640-3797$$aTsivgoulis, Georgios$$b46
000912509 7001_ $$00000-0003-2003-5473$$aSheth, Kevin N.$$b47
000912509 7001_ $$00000-0003-1510-602X$$aAwad, Issam A.$$b48
000912509 7001_ $$00000-0002-8487-1238$$aSchwab, Stefan$$b49
000912509 7001_ $$00000-0002-9536-4258$$aHanley, Daniel F.$$b50
000912509 7001_ $$00000-0002-0992-8871$$aHuttner, Hagen B.$$b51
000912509 7001_ $$aSansing, Lauren$$b52
000912509 7001_ $$aMatouk, Charles C.$$b53
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000912509 7001_ $$aStösser, Sebastian$$b63
000912509 7001_ $$aLudolph, Albert Christian$$b64
000912509 7001_ $$aNueckel, Martin$$b65
000912509 7001_ $$aGlahn, Jörg$$b66
000912509 7001_ $$aStetefeld, Henning$$b67
000912509 7001_ $$aRahmig, Jan$$b68
000912509 7001_ $$aFisse, Anna Lena$$b69
000912509 7001_ $$aMichels, Peter$$b70
000912509 7001_ $$aSchwert, Henning$$b71
000912509 7001_ $$aHagemann, Georg$$b72
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000912509 7001_ $$aWöhrle, Johannes C.$$b74
000912509 7001_ $$aAlshammari, Fahid$$b75
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000912509 7001_ $$aBahner, Dirk$$b77
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000912509 7001_ $$aPalm, Frederick$$b79
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