TY  - JOUR
AU  - Kuramatsu, Joji B.
AU  - Gerner, Stefan T.
AU  - Ziai, Wendy
AU  - Bardutzky, Jürgen
AU  - Sembill, Jochen A.
AU  - Sprügel, Maximilian I.
AU  - Mrochen, Anne
AU  - Kölbl, Kathrin
AU  - Ram, Malathi
AU  - Avadhani, Radhika
AU  - Falcone, Guido J.
AU  - Selim, Magdy H.
AU  - Lioutas, Vasileios-Arsenios
AU  - Endres, Matthias
AU  - Zweynert, Sarah
AU  - Vajkoczy, Peter
AU  - Ringleb, Peter A.
AU  - Purrucker, Jan C.
AU  - Volkmann, Jens
AU  - Neugebauer, Hermann
AU  - Erbguth, Frank
AU  - Schellinger, Peter D.
AU  - Knappe, Ulrich J.
AU  - Fink, Gereon Rudolf
AU  - Dohmen, Christian
AU  - Minnerup, Jens
AU  - Reichmann, Heinz
AU  - Schneider, Hauke
AU  - Röther, Joachim
AU  - Reimann, Gernot
AU  - Schwarz, Michael
AU  - Bäzner, Hansjörg
AU  - Claßen, Joseph
AU  - Michalski, Dominik
AU  - Witte, Otto W.
AU  - Günther, Albrecht
AU  - Hamann, Gerhard F.
AU  - Lücking, Hannes
AU  - Dörfler, Arnd
AU  - Ishfaq, Muhammad Fawad
AU  - Chang, Jason J.
AU  - Testai, Fernando D.
AU  - Woo, Daniel
AU  - Alexandrov, Andrei V.
AU  - Staykov, Dimitre
AU  - Goyal, Nitin
AU  - Tsivgoulis, Georgios
AU  - Sheth, Kevin N.
AU  - Awad, Issam A.
AU  - Schwab, Stefan
AU  - Hanley, Daniel F.
AU  - Huttner, Hagen B.
AU  - Sansing, Lauren
AU  - Matouk, Charles C.
AU  - Leasure, Audrey
AU  - Sobesky, Jan
AU  - Bauer, Miriam
AU  - Schurig, Johannes
AU  - Rizos, Timolaos
AU  - Haeusler, Karl Georg
AU  - Müllges, Wolfgang
AU  - Kraft, Peter
AU  - Schubert, Anna-Lena
AU  - Stösser, Sebastian
AU  - Ludolph, Albert Christian
AU  - Nueckel, Martin
AU  - Glahn, Jörg
AU  - Stetefeld, Henning
AU  - Rahmig, Jan
AU  - Fisse, Anna Lena
AU  - Michels, Peter
AU  - Schwert, Henning
AU  - Hagemann, Georg
AU  - Rakers, Florian
AU  - Wöhrle, Johannes C.
AU  - Alshammari, Fahid
AU  - Horn, Markus
AU  - Bahner, Dirk
AU  - Urbanek, Christian
AU  - Palm, Frederick
AU  - Grau, Armin
TI  - Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis
JO  - Stroke
VL  - 53
IS  - 9
SN  - 0039-2499
CY  - Philadelphia, Pa.
PB  - Lippincott Williams & Wilkins
M1  - FZJ-2022-05682
SP  - 2876 - 2886
PY  - 2022
AB  - Background:In patients with intracerebral hemorrhage (ICH), the presence of intraventricular hemorrhage constitutes a promising therapeutic target. Intraventricular fibrinolysis (IVF) reduces mortality, yet impact on functional disability remains unclear. Thus, we aimed to determine the influence of IVF on functional outcomes.Methods:This individual participant data meta-analysis pooled 1501 patients from 2 randomized trials and 7 observational studies enrolled during 2004 to 2015. We compared IVF versus standard of care (including placebo) in patients treated with external ventricular drainage due to acute hydrocephalus caused by ICH with intraventricular hemorrhage. The primary outcome was functional disability evaluated by the modified Rankin Scale (mRS; range: 0–6, lower scores indicating less disability) at 6 months, dichotomized into mRS score: 0 to 3 versus mRS: 4 to 6. Secondary outcomes included ordinal-shift analysis, all-cause mortality, and intracranial adverse events. Confounding and bias were adjusted by random effects and doubly robust models to calculate odds ratios and absolute treatment effects (ATE).
LB  - PUB:(DE-HGF)16
C6  - 35521958
UR  - <Go to ISI:>//WOS:000841531000035
DO  - DOI:10.1161/STROKEAHA.121.038455
UR  - https://juser.fz-juelich.de/record/912509
ER  -