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@ARTICLE{Kuramatsu:912509,
      author       = {Kuramatsu, Joji B. and Gerner, Stefan T. and Ziai, Wendy
                      and Bardutzky, Jürgen and Sembill, Jochen A. and Sprügel,
                      Maximilian I. and Mrochen, Anne and Kölbl, Kathrin and Ram,
                      Malathi and Avadhani, Radhika and Falcone, Guido J. and
                      Selim, Magdy H. and Lioutas, Vasileios-Arsenios and Endres,
                      Matthias and Zweynert, Sarah and Vajkoczy, Peter and
                      Ringleb, Peter A. and Purrucker, Jan C. and Volkmann, Jens
                      and Neugebauer, Hermann and Erbguth, Frank and Schellinger,
                      Peter D. and Knappe, Ulrich J. and Fink, Gereon Rudolf and
                      Dohmen, Christian and Minnerup, Jens and Reichmann, Heinz
                      and Schneider, Hauke and Röther, Joachim and Reimann,
                      Gernot and Schwarz, Michael and Bäzner, Hansjörg and
                      Claßen, Joseph and Michalski, Dominik and Witte, Otto W.
                      and Günther, Albrecht and Hamann, Gerhard F. and Lücking,
                      Hannes and Dörfler, Arnd and Ishfaq, Muhammad Fawad and
                      Chang, Jason J. and Testai, Fernando D. and Woo, Daniel and
                      Alexandrov, Andrei V. and Staykov, Dimitre and Goyal, Nitin
                      and Tsivgoulis, Georgios and Sheth, Kevin N. and Awad, Issam
                      A. and Schwab, Stefan and Hanley, Daniel F. and Huttner,
                      Hagen B. and Sansing, Lauren and Matouk, Charles C. and
                      Leasure, Audrey and Sobesky, Jan and Bauer, Miriam and
                      Schurig, Johannes and Rizos, Timolaos and Haeusler, Karl
                      Georg and Müllges, Wolfgang and Kraft, Peter and Schubert,
                      Anna-Lena and Stösser, Sebastian and Ludolph, Albert
                      Christian and Nueckel, Martin and Glahn, Jörg and
                      Stetefeld, Henning and Rahmig, Jan and Fisse, Anna Lena and
                      Michels, Peter and Schwert, Henning and Hagemann, Georg and
                      Rakers, Florian and Wöhrle, Johannes C. and Alshammari,
                      Fahid and Horn, Markus and Bahner, Dirk and Urbanek,
                      Christian and Palm, Frederick and Grau, Armin},
      title        = {{A}ssociation of {I}ntraventricular {F}ibrinolysis {W}ith
                      {C}linical {O}utcomes in {I}ntracerebral {H}emorrhage: {A}n
                      {I}ndividual {P}articipant {D}ata {M}eta-{A}nalysis},
      journal      = {Stroke},
      volume       = {53},
      number       = {9},
      issn         = {0039-2499},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {FZJ-2022-05682},
      pages        = {2876 - 2886},
      year         = {2022},
      abstract     = {Background:In patients with intracerebral hemorrhage (ICH),
                      the presence of intraventricular hemorrhage constitutes a
                      promising therapeutic target. Intraventricular fibrinolysis
                      (IVF) reduces mortality, yet impact on functional disability
                      remains unclear. Thus, we aimed to determine the influence
                      of IVF on functional outcomes.Methods:This individual
                      participant data meta-analysis pooled 1501 patients from 2
                      randomized trials and 7 observational studies enrolled
                      during 2004 to 2015. We compared IVF versus standard of care
                      (including placebo) in patients treated with external
                      ventricular drainage due to acute hydrocephalus caused by
                      ICH with intraventricular hemorrhage. The primary outcome
                      was functional disability evaluated by the modified Rankin
                      Scale (mRS; range: 0–6, lower scores indicating less
                      disability) at 6 months, dichotomized into mRS score: 0 to 3
                      versus mRS: 4 to 6. Secondary outcomes included
                      ordinal-shift analysis, all-cause mortality, and
                      intracranial adverse events. Confounding and bias were
                      adjusted by random effects and doubly robust models to
                      calculate odds ratios and absolute treatment effects (ATE).},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35521958},
      UT           = {WOS:000841531000035},
      doi          = {10.1161/STROKEAHA.121.038455},
      url          = {https://juser.fz-juelich.de/record/912509},
}