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@ARTICLE{Latarnik:912536,
      author       = {Latarnik, S. and Stahl, J. and Vossel, S. and Grefkes, C.
                      and Fink, G. R. and Weiss-Blankenhorn, Peter},
      title        = {{T}he impact of apraxia and neglect on early rehabilitation
                      outcome after stroke},
      journal      = {Neurological research and practice},
      volume       = {4},
      number       = {1},
      issn         = {2524-3489},
      address      = {[London]},
      publisher    = {BioMed Central},
      reportid     = {FZJ-2022-05709},
      pages        = {46},
      year         = {2022},
      abstract     = {BackgroundThis study aims to characterize the impact of
                      apraxia and visuospatial neglect on stroke patients’
                      cognitive and functional outcomes during early
                      rehabilitation. Prior work implies an unfavorable effect of
                      visuospatial neglect on rehabilitation; however, previous
                      findings remain ambiguous and primarily considered long-term
                      effects. Even less is known about the impact of apraxia on
                      rehabilitation outcomes. Although clinicians agree on the
                      significance of the first few weeks after stroke for the
                      course of rehabilitation, studies exploring the impact of
                      neglect and apraxia in this early rehabilitation period
                      remain scarce.MethodsBased on a screening of 515
                      hospitalized stroke patients from an early rehabilitation
                      ward, 150 stroke patients (75 left-hemispheric strokes, 75
                      right hemispheric strokes) fulfilled the inclusion criteria
                      and were enrolled in this observational, longitudinal study.
                      The patients’ cognitive and functional statuses were
                      documented at admission to the early rehabilitation ward and
                      discharge. Also, detailed apraxia and neglect assessments
                      were performed at midterm. The predictive values of age and
                      apraxia and neglect severity (as reflected in two components
                      from a principal component analysis of the neglect and
                      apraxia assessments) for cognitive and functional outcomes
                      at discharge were evaluated by multiple regression
                      analyses.ResultsBesides the expected influence of the
                      respective variables at admission, we observed a significant
                      effect of apraxia severity on the cognitive outcome at
                      discharge. Moreover, neglect severity predicted the Early
                      Rehabilitation Barthel Index (Frühreha-Barthel-Index) at
                      discharge. Supplementary moderator analysis revealed a
                      differential effect of neglect severity on the cognitive
                      outcome depending on the affected hemisphere.ConclusionData
                      indicate a strong association between apraxia and
                      visuospatial neglect and early rehabilitation outcomes after
                      stroke.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36154935},
      UT           = {WOS:001166769500046},
      doi          = {10.1186/s42466-022-00211-x},
      url          = {https://juser.fz-juelich.de/record/912536},
}