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@ARTICLE{Klein:912541,
      author       = {Klein, Ines and Boenert, Janne and Lange, Felix and
                      Christensen, Britt and Wassermann, Meike K. and Wiesen,
                      Martin H. J. and Olschewski, Daniel Navin and Rabenstein,
                      Monika and Müller, Carsten and Lehmann, Helmar C. and Fink,
                      Gereon Rudolf and Schroeter, Michael and Rueger, Maria Adele
                      and Vay, Sabine Ulrike},
      title        = {{G}lia from the central and peripheral nervous system are
                      differentially affected by paclitaxel chemotherapy via
                      modulating their neuroinflammatory and neuroregenerative
                      properties},
      journal      = {Frontiers in pharmacology},
      volume       = {13},
      issn         = {1663-9812},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {FZJ-2022-05714},
      pages        = {1038285},
      year         = {2022},
      abstract     = {Glia are critical players in defining synaptic contacts and
                      maintaining neuronal homeostasis. Both astrocytes as glia of
                      the central nervous system (CNS), as well as satellite glial
                      cells (SGC) as glia of the peripheral nervous system (PNS),
                      intimately interact with microglia, especially under
                      pathological conditions when glia regulate degenerative as
                      well as regenerative processes. The chemotherapeutic agent
                      paclitaxel evokes peripheral neuropathy and cognitive
                      deficits; however, the mechanisms underlying these diverse
                      clinical side effects are unclear. We aimed to elucidate the
                      direct effects of paclitaxel on the function of astrocytes,
                      microglia, and SGCs, and their glia-glia and neuronal-glia
                      interactions. After intravenous application, paclitaxel was
                      present in the dorsal root ganglia of the PNS and the CNS of
                      rodents. In vitro, SGC enhanced the expression of
                      pro-inflammatory factors and reduced the expression of
                      neurotrophic factor NT-3 upon exposure to paclitaxel,
                      resulting in predominantly neurotoxic effects. Likewise,
                      paclitaxel induced a switch towards a pro-inflammatory
                      phenotype in microglia, exerting neurotoxicity. In contrast,
                      astrocytes expressed neuroprotective markers and
                      increasingly expressed S100A10 after paclitaxel exposure.
                      Astrocytes, and to a lesser extent SGCs, had regulatory
                      effects on microglia independent of paclitaxel exposure.
                      Data suggest that paclitaxel differentially modulates glia
                      cells regarding their (neuro-) inflammatory and (neuro-)
                      regenerative properties and also affects their interaction.
                      By elucidating those processes, our data contribute to the
                      understanding of the mechanistic pathways of
                      paclitaxel-induced side effects in CNS and PNS.Keywords:
                      paclitaxel, chemotherapy-related neurotoxicity,
                      neuroinflammation, astrocytes, microglia, satellite glia
                      cells, neural stem cells, BDNF (brain derived neurotrophic
                      factor)},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36408236},
      UT           = {WOS:000885546500001},
      doi          = {10.3389/fphar.2022.1038285},
      url          = {https://juser.fz-juelich.de/record/912541},
}