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@ARTICLE{Schild:912542,
      author       = {Schild, Ann-Katrin and Goereci, Yasemin and Scharfenberg,
                      Daniel and Klein, Kim and Lülling, Joachim and Meiberth,
                      Dix and Schweitzer, Finja and Stürmer, Sophie and Zeyen,
                      Philip and Sahin, Derya and Fink, Gereon R. and Jessen,
                      Frank and Franke, Christiana and Onur, Oezguer A. and
                      Kessler, Josef and Warnke, Clemens and Maier, Franziska},
      title        = {{M}ultidomain cognitive impairment in non-hospitalized
                      patients with the post-{COVID}-19 syndrome: results from a
                      prospective monocentric cohort},
      journal      = {Journal of neurology},
      volume       = {270},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {FZJ-2022-05715},
      pages        = {1215-1223},
      year         = {2023},
      abstract     = {BackgroundA fraction of patients with asymptomatic to
                      mild/moderate acute COVID-19 disease report cognitive
                      deficits as part of the post-COVID-19 syndrome. This study
                      aimed to assess the neuropsychological profile of these
                      patients.MethodsAssessment at baseline (three months or more
                      following acute COVID-19) of a monocentric prospective
                      cohort of patients with post-COVID-19 syndrome. Multidomain
                      neuropsychological tests were performed, and questionnaires
                      on depression, anxiety, fatigue, sleep, and general health
                      status were administered.ResultsOf the 58 patients screened,
                      six were excluded due to possible alternative causes of
                      cognitive impairment (major depression, neurodegenerative
                      disease). Of the remaining 52 individuals, only one had a
                      below-threshold screening result on Mini-Mental State
                      Examination, and 13 scored below the cut-off on Montreal
                      Cognitive Assessment. Extended neuropsychological testing
                      revealed a neurocognitive disorder (NCD) in 31 $(59.6\%)$
                      participants with minor NCD in the majority of cases
                      (n = 26). In patients with NCD, the cognitive domains
                      learning/memory and executive functions were impaired in
                      $60.7\%,$ complex attention in $51.6\%,$ language in
                      $35.5\%,$ and perceptual-motor function in $29.0\%.$
                      Cognitive profiles were associated with daytime sleepiness
                      but not with depression, anxiety, sleep quality, total
                      general health status, or fatigue.ConclusionNeurocognitive
                      impairment can be confirmed in around $60\%$ of individuals
                      with self-reported deficits as part of post-COVID-19
                      syndrome following a mild acute COVID-19 disease course.
                      Notably, screening tests cannot reliably detect this
                      dysfunction. Standard psychiatric assessments showed no
                      association with cognitive profiles. Longitudinal studies
                      are needed to further evaluate the course of neurocognitive
                      deficits and clarify pathophysiology.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36422669},
      UT           = {WOS:000887862600002},
      doi          = {10.1007/s00415-022-11444-w},
      url          = {https://juser.fz-juelich.de/record/912542},
}