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000916032 0247_ $$2doi$$a10.1523/JNEUROSCI.0658-22.2022
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000916032 1001_ $$0P:(DE-HGF)0$$aNiedernhuber, Maria$$b0$$eCorresponding author
000916032 245__ $$aSensory target detection at local and global timescales reveals a hierarchy of supramodal dynamics in the human cortex
000916032 260__ $$aWashington, DC$$bSoc.$$c2022
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000916032 520__ $$aTo ensure survival in a dynamic environment, the human neocortex monitors input streams from different sensory organs for important sensory events. Which principles govern whether different senses share common or modality-specific brain networks for sensory target detection? We examined whether complex targets evoke sustained supramodal activity while simple targets rely on modality-specific networks with short-lived supramodal contributions. In a series of hierarchical multisensory target detection studies (n = 77, of either sex) using EEG, we applied a temporal cross-decoding approach to dissociate supramodal and modality-specific cortical dynamics elicited by rule-based global and feature-based local sensory deviations within and between the visual, somatosensory, and auditory modality. Our data show that each sense implements a cortical hierarchy orchestrating supramodal target detection responses, which operate at local and global timescales in successive processing stages. Across different sensory modalities, simple feature-based sensory deviations presented in temporal vicinity to a monotonous input stream triggered a mismatch negativity-like local signal which decayed quickly and early, whereas complex rule-based targets tracked across time evoked a P3b-like global neural response which generalized across a late time window. Converging results from temporal cross-modality decoding analyses across different datasets, we reveal that global neural responses are sustained in a supramodal higher-order network, whereas local neural responses canonically thought to rely on modality-specific regions evolve into short-lived supramodal activity. Together, our findings demonstrate that cortical organization largely follows a gradient in which short-lived modality-specific as well as supramodal processes dominate local responses, whereas higher-order processes encode temporally extended abstract supramodal information fed forward from modality-specific cortices.
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000916032 7001_ $$0P:(DE-Juel1)185083$$aRaimondo, Federico$$b1
000916032 7001_ $$0P:(DE-HGF)0$$aSitt, Jacobo D.$$b2
000916032 7001_ $$0P:(DE-HGF)0$$aBekinschtein, Tristan A.$$b3
000916032 77318 $$2Crossref$$3journal-article$$a10.1523/jneurosci.0658-22.2022$$bSociety for Neuroscience$$d2022-10-12$$pJN-RM-0658-22$$tThe Journal of Neuroscience$$x0270-6474$$y2022
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000916032 8564_ $$uhttps://juser.fz-juelich.de/record/916032/files/8729.full.pdf$$yPublished on 2022-11-16. Available in OpenAccess from 2023-05-16.
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