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@ARTICLE{Niedernhuber:916032,
      author       = {Niedernhuber, Maria and Raimondo, Federico and Sitt, Jacobo
                      D. and Bekinschtein, Tristan A.},
      title        = {{S}ensory target detection at local and global timescales
                      reveals a hierarchy of supramodal dynamics in the human
                      cortex},
      journal      = {The journal of neuroscience},
      volume       = {42},
      number       = {46},
      issn         = {0270-6474},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2022-05878},
      pages        = {JN-RM-0658-22},
      year         = {2022},
      abstract     = {To ensure survival in a dynamic environment, the human
                      neocortex monitors input streams from different sensory
                      organs for important sensory events. Which principles govern
                      whether different senses share common or modality-specific
                      brain networks for sensory target detection? We examined
                      whether complex targets evoke sustained supramodal activity
                      while simple targets rely on modality-specific networks with
                      short-lived supramodal contributions. In a series of
                      hierarchical multisensory target detection studies (n = 77,
                      of either sex) using EEG, we applied a temporal
                      cross-decoding approach to dissociate supramodal and
                      modality-specific cortical dynamics elicited by rule-based
                      global and feature-based local sensory deviations within and
                      between the visual, somatosensory, and auditory modality.
                      Our data show that each sense implements a cortical
                      hierarchy orchestrating supramodal target detection
                      responses, which operate at local and global timescales in
                      successive processing stages. Across different sensory
                      modalities, simple feature-based sensory deviations
                      presented in temporal vicinity to a monotonous input stream
                      triggered a mismatch negativity-like local signal which
                      decayed quickly and early, whereas complex rule-based
                      targets tracked across time evoked a P3b-like global neural
                      response which generalized across a late time window.
                      Converging results from temporal cross-modality decoding
                      analyses across different datasets, we reveal that global
                      neural responses are sustained in a supramodal higher-order
                      network, whereas local neural responses canonically thought
                      to rely on modality-specific regions evolve into short-lived
                      supramodal activity. Together, our findings demonstrate that
                      cortical organization largely follows a gradient in which
                      short-lived modality-specific as well as supramodal
                      processes dominate local responses, whereas higher-order
                      processes encode temporally extended abstract supramodal
                      information fed forward from modality-specific cortices.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36223999},
      UT           = {WOS:000903701700013},
      doi          = {10.1523/JNEUROSCI.0658-22.2022},
      url          = {https://juser.fz-juelich.de/record/916032},
}