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@ARTICLE{Pantoja:916050,
      author       = {Pantoja, Christian and Zweckstetter, Markus and Rezaie
                      Ghaleh, Nasrollah},
      title        = {{D}ynamical component exchange in a model phase separating
                      system: an {NMR}-based approach},
      journal      = {Physical chemistry, chemical physics},
      volume       = {24},
      number       = {10},
      issn         = {1463-9076},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {FZJ-2022-05896},
      pages        = {6169 - 6175},
      year         = {2022},
      abstract     = {Biomolecular phase separation plays a key role in the
                      spatial organization of cellular activities. Dynamic
                      formation and rapid component exchange between phase
                      separated cellular bodies and their environment are crucial
                      for their function. Here, we employ a well-established phase
                      separating model system, namely, a triethylamine
                      (TEA)–water mixture, and develop an NMR approach to detect
                      the exchange of scaffolding TEA molecules between separate
                      phases and determine the underlying exchange rate. We
                      further demonstrate how the advantageous NMR properties of
                      fluorine nuclei provide access to otherwise inaccessible
                      exchange processes of a client molecule. The developed
                      NMR-based approach allows quantitative monitoring of the
                      effect of regulatory factors on component exchange and
                      facilitates “exchange”-based screening and optimization
                      of small molecules against druggable biomolecular targets
                      located inside condensed phases.},
      cin          = {IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35229098},
      UT           = {WOS:000762379400001},
      doi          = {10.1039/D2CP00042C},
      url          = {https://juser.fz-juelich.de/record/916050},
}