%0 Journal Article
%A Shokoohimehr, Pegah
%A Cepkenovic, Bogdana
%A Milos, Frano
%A Bednár, Justus
%A Hassani, Hossein
%A Maybeck, Vanessa
%A Offenhäusser, Andreas
%T High‐Aspect‐Ratio Nanoelectrodes Enable Long‐Term Recordings of Neuronal Signals with Subthreshold Resolution
%J Small
%V 18
%N 22
%@ 1613-6810
%C Weinheim
%I Wiley-VCH
%M FZJ-2022-05921
%P 2200053 -
%D 2022
%X The further development of neurochips requires high-density and high-resolution recordings that also allow neuronal signals to be observed over a long period of time. Expanding fields of network neuroscience and neuromorphic engineering demand the multiparallel and direct estimations of synaptic weights, and the key objective is to construct a device that also records subthreshold events. Recently, 3D nanostructures with a high aspect ratio have become a particularly suitable interface between neurons and electronic devices, since the excellent mechanical coupling to the neuronal cell membrane allows very high signal-to-noise ratio recordings. In the light of an increasing demand for a stable, noninvasive and long-term recording at subthreshold resolution, a combination of vertical nanostraws with nanocavities is presented. These structures provide a spontaneous tight coupling with rat cortical neurons, resulting in high amplitude sensitivity and postsynaptic resolution capability, as directly confirmed by combined patch-clamp and microelectrode array measurements.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 35527345
%U <Go to ISI:>//WOS:000792050700001
%R 10.1002/smll.202200053
%U https://juser.fz-juelich.de/record/916075