TY  - JOUR
AU  - Shokoohimehr, Pegah
AU  - Cepkenovic, Bogdana
AU  - Milos, Frano
AU  - Bednár, Justus
AU  - Hassani, Hossein
AU  - Maybeck, Vanessa
AU  - Offenhäusser, Andreas
TI  - High‐Aspect‐Ratio Nanoelectrodes Enable Long‐Term Recordings of Neuronal Signals with Subthreshold Resolution
JO  - Small
VL  - 18
IS  - 22
SN  - 1613-6810
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2022-05921
SP  - 2200053 -
PY  - 2022
AB  - The further development of neurochips requires high-density and high-resolution recordings that also allow neuronal signals to be observed over a long period of time. Expanding fields of network neuroscience and neuromorphic engineering demand the multiparallel and direct estimations of synaptic weights, and the key objective is to construct a device that also records subthreshold events. Recently, 3D nanostructures with a high aspect ratio have become a particularly suitable interface between neurons and electronic devices, since the excellent mechanical coupling to the neuronal cell membrane allows very high signal-to-noise ratio recordings. In the light of an increasing demand for a stable, noninvasive and long-term recording at subthreshold resolution, a combination of vertical nanostraws with nanocavities is presented. These structures provide a spontaneous tight coupling with rat cortical neurons, resulting in high amplitude sensitivity and postsynaptic resolution capability, as directly confirmed by combined patch-clamp and microelectrode array measurements.
LB  - PUB:(DE-HGF)16
C6  - 35527345
UR  - <Go to ISI:>//WOS:000792050700001
DO  - DOI:10.1002/smll.202200053
UR  - https://juser.fz-juelich.de/record/916075
ER  -