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@INPROCEEDINGS{MoralesGregorio:916173,
      author       = {Morales-Gregorio, Aitor},
      title        = {{F}eedback modulation of neural manifolds in macaque
                      primary visual cortex},
      reportid     = {FZJ-2022-05993},
      year         = {2022},
      abstract     = {High-dimensional brain activity is in many cases organized
                      into lower-dimensional neural manifolds [1,2]. Feedback from
                      V4 to V1 is known to mediate visual attention [3] and
                      computational work has shown that it can also rotate neural
                      manifolds in a context-dependent manner [4]. However,
                      whether feedback signals can modulate neural manifolds in
                      vivo remains to be ascertained. Here, we studied the neural
                      manifolds in macaque (Macaca mulatta) visual cortex during
                      resting state [5] and found two distinct high-dimensional
                      clusters in the activity. The clusters were primarily
                      correlated with behavioral state (eye closure) and had
                      distinct dimensionality. Granger causality analysis revealed
                      that feedback from V4 to V1 was significantly stronger
                      during the eyes-open periods. Finally, spiking neuron model
                      simulations confirmed that signals mimicking V4-to-V1
                      feedback can modulate neural manifolds. Taken together, the
                      data analysis and simulations suggest that feedback signals
                      actively modulate neural manifolds in the visual cortex of
                      the macaque.References:[1] Stringer et al. (2020). Nature
                      571, 361-365. https://doi.org/10.1038/s41586-019-1346-5[2]
                      Singh et al. (2008). Journal of Vision 8(8), 11.
                      https://doi.org/10.1167/8.8.11[3] Poort et al. (2012).
                      Neuron 75 (1), 143-156.
                      https://doi.org/10.1016/j.neuron.2012.04.032[4] Naumann et
                      al. (2022). eLife 11, 76096.
                      https://doi.org/10.7554/eLife.76096[5] Chen*,
                      Morales-Gregorio* et al. (2022). Scientific Data 9 (1), 77.
                      https://doi.org/10.1038/s41597-022-01180-1},
      organization  = {Redwood seminar hosted by Prof. Fritz
                       Sommer, UC Berkeley (USA)},
      subtyp        = {Invited},
      cin          = {INM-6 / IAS-6 / INM-10},
      cid          = {I:(DE-Juel1)INM-6-20090406 / I:(DE-Juel1)IAS-6-20130828 /
                      I:(DE-Juel1)INM-10-20170113},
      pnm          = {5231 - Neuroscientific Foundations (POF4-523) / HBP SGA3 -
                      Human Brain Project Specific Grant Agreement 3 (945539) /
                      SPP 2041 347572269 - Integration von
                      Multiskalen-Konnektivität und Gehirnarchitektur in einem
                      supercomputergestützten Modell der menschlichen
                      Großhirnrinde (347572269) / GRK 2416 - GRK 2416:
                      MultiSenses-MultiScales: Neue Ansätze zur Aufklärung
                      neuronaler multisensorischer Integration (368482240)},
      pid          = {G:(DE-HGF)POF4-5231 / G:(EU-Grant)945539 /
                      G:(GEPRIS)347572269 / G:(GEPRIS)368482240},
      typ          = {PUB:(DE-HGF)31},
      url          = {https://juser.fz-juelich.de/record/916173},
}