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000916530 1001_ $$0P:(DE-Juel1)168267$$aBorggräfe, Jan$$b0
000916530 245__ $$aThe architecture of the 10‐23 DNA zyme and its implications for DNA ‐mediated catalysis
000916530 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2023
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000916530 520__ $$aUnderstanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is essential not only for our understanding of the fundamental properties of catalytic nucleic acids in general, but may well be the key to unravelling their full potential via tailored modifications. Our recent findings contributed to the endeavour to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz's unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. Here, we discuss key features of our findings and compare them to other studies on similar systems.
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000916530 7001_ $$0P:(DE-Juel1)174133$$aGertzen, Christoph G. W.$$b1
000916530 7001_ $$0P:(DE-Juel1)161140$$aViegas, Aldino$$b2
000916530 7001_ $$0P:(DE-Juel1)172663$$aGohlke, Holger$$b3$$eCorresponding author
000916530 7001_ $$0P:(DE-Juel1)156341$$aEtzkorn, Manuel$$b4$$eCorresponding author
000916530 773__ $$0PERI:(DE-600)2172518-4$$a10.1111/febs.16698$$gp. febs.16698$$n8$$p2011-2021$$tThe FEBS journal$$v290$$x0014-2956$$yNA
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