TY  - JOUR
AU  - Borggräfe, Jan
AU  - Gertzen, Christoph G. W.
AU  - Viegas, Aldino
AU  - Gohlke, Holger
AU  - Etzkorn, Manuel
TI  - The architecture of the 10‐23 DNA zyme and its implications for DNA ‐mediated catalysis
JO  - The FEBS journal
VL  - 290
IS  - 8
SN  - 0014-2956
CY  - Oxford [u.a.]
PB  - Wiley-Blackwell
M1  - FZJ-2022-06314
SP  - 2011-2021
PY  - 2023
AB  - Understanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is essential not only for our understanding of the fundamental properties of catalytic nucleic acids in general, but may well be the key to unravelling their full potential via tailored modifications. Our recent findings contributed to the endeavour to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz's unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. Here, we discuss key features of our findings and compare them to other studies on similar systems.
LB  - PUB:(DE-HGF)16
C6  - 36478072
UR  - <Go to ISI:>//WOS:000899460700001
DO  - DOI:10.1111/febs.16698
UR  - https://juser.fz-juelich.de/record/916530
ER  -