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@ARTICLE{Borggrfe:916530,
      author       = {Borggräfe, Jan and Gertzen, Christoph G. W. and Viegas,
                      Aldino and Gohlke, Holger and Etzkorn, Manuel},
      title        = {{T}he architecture of the 10‐23 {DNA} zyme and its
                      implications for {DNA} ‐mediated catalysis},
      journal      = {The FEBS journal},
      volume       = {290},
      number       = {8},
      issn         = {0014-2956},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2022-06314},
      pages        = {2011-2021},
      year         = {2023},
      abstract     = {Understanding the molecular features of catalytically
                      active DNA sequences, so-called DNAzymes, is essential not
                      only for our understanding of the fundamental properties of
                      catalytic nucleic acids in general, but may well be the key
                      to unravelling their full potential via tailored
                      modifications. Our recent findings contributed to the
                      endeavour to assemble a mechanistic picture of DNA-mediated
                      catalysis by providing high-resolution structural insights
                      into the 10-23 DNAzyme (Dz) and exposing a complex interplay
                      between the Dz's unique molecular architecture,
                      conformational plasticity, and dynamic modulation by metal
                      ions as central elements of the DNA catalyst. Here, we
                      discuss key features of our findings and compare them to
                      other studies on similar systems.},
      cin          = {IBG-4 / IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBG-4-20200403 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {2171 - Biological and environmental resources for
                      sustainable use (POF4-217) / 5241 - Molecular Information
                      Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-2171 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36478072},
      UT           = {WOS:000899460700001},
      doi          = {10.1111/febs.16698},
      url          = {https://juser.fz-juelich.de/record/916530},
}