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| 001 | 916667 | ||
| 005 | 20231027114350.0 | ||
| 024 | 7 | _ | |a 10.1002/chem.202203493 |2 doi |
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| 037 | _ | _ | |a FZJ-2023-00019 |
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| 100 | 1 | _ | |a Abyzov, Anton |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Fast Motions Dominate Dynamics of Intrinsically Disordered Tau Protein at High Temperatures |
| 260 | _ | _ | |a Weinheim |c 2023 |b Wiley-VCH |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1679990948_1902 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Reorientational dynamics of intrinsically disordered proteins (IDPs) contain multiple motions often clustered around three motional modes: ultrafast librational motions of amide groups, fast local backbone conformational fluctuations and slow chain segmental motions. This dynamic picture is mainly based on 15N NMR relaxation studies of IDPs at relatively low temperatures where the amide-water proton exchange rates are sufficiently small. Less is known, however, about the dynamics of IDPs at more physiological temperatures. Here, we investigate protein dynamics in a 441-residue long IDP, tau protein, in the temperature range from 0-25 °C, using 15N NMR relaxation rates and spectral density analysis. While at these temperatures relaxation rates are still better described in terms of amide group librational motions, local backbone dynamics and chain segmental motions, the temperature-dependent trend of spectral densities suggests that the timescales of fast backbone conformational fluctuations and slower chain segmental motions might become inseparable at higher temperatures. Our data demonstrate the remarkable dynamic plasticity of this prototypical IDP and highlight the need for dynamic studies of IDPs at multiple temperatures. |
| 536 | _ | _ | |a 5241 - Molecular Information Processing in Cellular Systems (POF4-524) |0 G:(DE-HGF)POF4-5241 |c POF4-524 |f POF IV |x 0 |
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| 700 | 1 | _ | |a Mandelkow, Eckhard |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Zweckstetter, Markus |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Rezaie Ghaleh, Nasrollah |0 P:(DE-Juel1)194492 |b 3 |e Corresponding author |
| 773 | _ | _ | |a 10.1002/chem.202203493 |g p. chem.202203493 |0 PERI:(DE-600)1478547-X |n 17 |p e202203493 |t Chemistry - a European journal |v 29 |y 2023 |x 0947-6539 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/916667/files/Chemistry%20A%20European%20J%20-%202022%20-%20Abyzov%20-%20Fast%20Motions%20Dominate%20Dynamics%20of%20Intrinsically%20Disordered%20Tau%20Protein%20at%20High.pdf |y OpenAccess |
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