%0 Journal Article
%A Altomare, Daniele
%A Collij, Lyduine
%A Caprioglio, Camilla
%A Scheltens, Philip
%A van Berckel, Bart N. M.
%A Alves, Isadora Lopes
%A Berkhof, Johannes
%A de Gier, Yvonne
%A Garibotto, Valentina
%A Moro, Christian
%A Poitrine, Léa
%A Delrieu, Julien
%A Payoux, Pierre
%A Saint-Aubert, Laure
%A Molinuevo, José Luis
%A Grau-Rivera, Oriol
%A Gispert, Juan-Domingo
%A Minguillón, Carolina
%A Fauria, Karine
%A Sanchez, Marta Felez
%A Rădoi, Andreea
%A Drzezga, Alexander
%A Jessen, Frank
%A Escher, Claus
%A Zeyen, Philip
%A Nordberg, Agneta
%A Savitcheva, Irina
%A Jelic, Vesna
%A Walker, Zuzana
%A Lee, Ho-Yun
%A Lee, Lean
%A Demonet, Jean-François
%A Plaza Wuthrich, Sonia
%A Gismondi, Rossella
%A Farrar, Gill
%A Barkhof, Frederik
%A Stephens, Andrew W.
%A Frisoni, Giovanni B.
%A Consortium, AMYPAD
%T Description of a European memory clinic cohort undergoing amyloid‐PET: The AMYPAD Diagnostic and Patient Management Study
%J Alzheimer's and dementia
%V 19
%N 3
%@ 1552-5260
%C Hoboken, NJ
%I Wiley
%M FZJ-2023-00157
%P 844-856
%D 2023
%X Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort.Methods: Participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice.Results: A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms.Discussion: The features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results.Keywords: Alzheimer's; PET; amyloid; dementia; memory clinic population; mild cognitive impairment; subjective cognitive decline.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 35715930
%U <Go to ISI:>//WOS:000812481000001
%R 10.1002/alz.12696
%U https://juser.fz-juelich.de/record/916865