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@ARTICLE{Wegen:916866,
      author       = {Wegen, Simone and van Heek, Lutz and Linde, Philipp and
                      Claus, Karina and Akuamoa-Boateng, Dennis and Baues,
                      Christian and Sharma, Shachi Jenny and Schomäcker, Klaus
                      and Fischer, Thomas and Roth, Katrin Sabine and Klußmann,
                      Jens Peter and Marnitz, Simone and Drzezga, Alexander and
                      Kobe, Carsten},
      title        = {{H}ead-to-{H}ead {C}omparison of
                      [68 {G}a]{G}a-{FAPI}-46-{PET}/{CT} and
                      [18{F}]{F}-{FDG}-{PET}/{CT} for {R}adiotherapy {P}lanning in
                      {H}ead and {N}eck {C}ancer},
      journal      = {Molecular imaging $\&$ biology},
      volume       = {24},
      number       = {6},
      issn         = {1536-1632},
      address      = {Cham},
      publisher    = {Springer Nature Switzerland},
      reportid     = {FZJ-2023-00158},
      pages        = {986 - 994},
      year         = {2022},
      abstract     = {Introduction: In head and neck cancers (HNCs), fibroblast
                      activation protein (FAP) is expressed by cancer-associated
                      fibroblasts (CAFs) in the tumor microenvironment.
                      Preliminary evidence suggests that detection and staging is
                      feasible with positron emission tomography (PET/CT) imaging
                      using [68 Ga]-radiolabeled inhibitors of FAP ([68
                      Ga]Ga-FAPI-46) in HNCs. This study aims to compare [68
                      Ga]Ga-FAPI-46 PET/CT and [18F]-fluorodeoxy-D-glucose
                      ([18F]F-FDG) PET/CT with a focus on improved target volume
                      definition and radiotherapy planning in patients with HNC
                      referred for chemoradiation.Methods: A total of 15 patients
                      with HNCs received both [68 Ga]Ga-FAPI-46 PET/CT and
                      [18F]F-FDG PET/CT with a thermoplastic mask, in addition to
                      initial tumor staging by conventional imaging with
                      contrast-enhanced CT and/or MRI. Mean intervals between
                      FAPI/FDG and FAPI/conventional imaging were 4 ± 20 and 17
                      ± 18 days, respectively. Location and number of suspicious
                      lesions revealed by the different procedures were recorded.
                      Subsequently, expert-generated gross tumor volumes (GTVs)
                      based on conventional imaging were compared to those based
                      on [18F]F-FDG and [68 Ga]Ga-FAPI-46 PET/CT to measure the
                      impact on subsequent radiation planning.Results: All
                      patients had focal FAPI uptake above background in tumor
                      lesions. Compared to FDG, tumor uptake (median SUVmax 10.2
                      vs. 7.3, p = 0.008) and tumor-to-background ratios were
                      significantly higher with FAPI than with FDG (SUVmean liver:
                      9.3 vs. 3.2, p < 0.001; SUVmean bloodpool: 6.9 vs. 4.0, p <
                      0.001). A total of 49 lesions were recorded. Of these, 40
                      $(82\%)$ were FDG+ and 41 $(84\%)$ were FAP+. There were 5
                      $(10\%)$ FAP+/FDG- lesions and 4 $(8\%)$ FAP-/FDG+ lesions.
                      Volumetrically, a significant difference was found between
                      the GTVs (median 57.9 ml in the FAPI-GTV, 42.5 ml in the
                      FDG-GTV, compared to 39.2 ml in the conventional-GTV).
                      Disease stage identified by FAPI PET/CT was mostly
                      concordant with FDG PET/CT. Compared to conventional
                      imaging, five patients $(33\%)$ were upstaged following
                      imaging with FAPI and FDG PET/CT.Conclusion: We demonstrate
                      that [68 Ga]Ga-FAPI-46 -PET/CT is useful for detecting tumor
                      lesions in patients with HNCs. There is now a need for
                      prospective randomized studies to confirm the role of [68
                      Ga]Ga-FAPI-46 PET/CT in relation to [18F]F-FDG PET/CT in
                      HNCs and to evaluate its impact on clinical
                      outcome.Keywords: FAPI; FDG/PET; Head and neck cancer;
                      PET-based; Radiotherapy planning.},
      cin          = {INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35771317},
      UT           = {WOS:000819277600001},
      doi          = {10.1007/s11307-022-01749-7},
      url          = {https://juser.fz-juelich.de/record/916866},
}