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@ARTICLE{Banwinkler:916868,
      author       = {Banwinkler, Magdalena and Dzialas, Verena and Hoenig, Merle
                      C. and van Eimeren, Thilo},
      title        = {{G}ray {M}atter {V}olume {L}oss in {P}roposed
                      {B}rain‐{F}irst and {B}ody‐{F}irst {P}arkinson's
                      {D}isease {S}ubtypes},
      journal      = {Movement disorders},
      volume       = {37},
      number       = {10},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2023-00160},
      pages        = {2066 - 2074},
      year         = {2022},
      abstract     = {Background: α-Synuclein pathology is associated with
                      neuronal degeneration in Parkinson's disease (PD) and
                      considered to sequentially spread across the brain (Braak
                      stages). According to a new hypothesis of distinct
                      α-synuclein spreading directions based on the initial site
                      of pathology, the "brain-first" spreading subtype would be
                      associated with a more asymmetric cerebral and nigrostriatal
                      pathology than the "body-first" subtype.Objective: Here, we
                      tested if proposed markers of brain-first PD (ie, higher
                      dopamine transporter [DaT] asymmetry; absence of rapid eye
                      movement sleep behavior disorder [RBD]) are associated with
                      a greater or more asymmetric reduction in gray matter volume
                      (GMV) in comparison to body-first PD.Methods: Data of 255 de
                      novo PD patients and 110 healthy controls (HCs) were
                      retrieved from the Parkinson's Progression Markers
                      Initiative. Structural magnetic resonance images were
                      preprocessed, and GMVs and their hemispherical asymmetry
                      were obtained for each of the neuropathologically defined
                      Braak stages. Group and correlation comparisons were
                      performed to assess differences in GMV and GMV asymmetry
                      between PD subtypes.Results: PD patients demonstrated
                      significantly smaller bilateral GMVs compared to HCs, in a
                      pattern denoting stage-dependent disease-related brain
                      atrophy. However, the degree of putaminal DaT asymmetry was
                      not associated with reduced GMV or higher GMV asymmetry.
                      Furthermore, RBD-negative and RBD-positive patients did not
                      demonstrate a significant difference in GMV or GMV
                      asymmetry.Conclusions: Our findings suggest that putative
                      brain-first and body-first patients do not present diverging
                      brain atrophy patterns. Although certainly not disproving
                      the brain-first/body-first spreading hypothesis, this study
                      fails to provide evidence in support of it. © 2022 The
                      Authors. Movement Disorders published by Wiley Periodicals
                      LLC on behalf of International Parkinson and Movement
                      Disorder Society.Keywords: dopamine transporter; rapid eye
                      movement sleep; rapid eye movement sleep behavior disorder;
                      α-synuclein spread.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {35943058},
      UT           = {WOS:000837651900001},
      doi          = {10.1002/mds.29172},
      url          = {https://juser.fz-juelich.de/record/916868},
}