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@ARTICLE{Chu:916869,
author = {Chu, Congying and Guan, Haoran and Xie, Sangma and Wang,
Yanpei and Luo, Jie and Zhao, Gai and Pan, Zhiying and Hu,
Mingming and Men, Weiwei and Tan, Shuping and Gao, Jia-Hong
and Qin, Shaozheng and He, Yong and Fan, Lingzhong and Dong,
Qi and Tao, Sha},
title = {{T}he {SACT} {T}emplate: {A} {H}uman {B}rain {D}iffusion
{T}ensor {T}emplate for {S}chool-age {C}hildren},
journal = {Neuroscience bulletin},
volume = {38},
number = {6},
issn = {1673-7067},
address = {Beijing},
publisher = {Tongfang Knowledge Network Technology Co., Ltd.},
reportid = {FZJ-2023-00161},
pages = {607 - 621},
year = {2022},
note = {Bitte Post-print ergänzenLiegt aktuell leider nicht vor;
wird nachgereicht!},
abstract = {School-age children are in a specific development stage
corresponding to juvenility, when the white matter of the
brain experiences ongoing maturation. Diffusion-weighted
magnetic resonance imaging (DWI), especially diffusion
tensor imaging (DTI), is extensively used to characterize
the maturation by assessing white matter properties in vivo.
In the analysis of DWI data, spatial normalization is
crucial for conducting inter-subject analyses or linking the
individual space with the reference space. Using
tensor-based registration with an appropriate diffusion
tensor template presents high accuracy regarding spatial
normalization. However, there is a lack of a standardized
diffusion tensor template dedicated to school-age children
with ongoing brain development. Here, we established the
school-age children diffusion tensor (SACT) template by
optimizing tensor reorientation on high-quality DTI data
from a large sample of cognitively normal participants aged
6-12 years. With an age-balanced design, the SACT template
represented the entire age range well by showing high
similarity to the age-specific templates. Compared with the
tensor template of adults, the SACT template revealed
significantly higher spatial normalization accuracy and
inter-subject coherence upon evaluation of subjects in two
different datasets of school-age children. A practical
application regarding the age associations with the
normalized DTI-derived data was conducted to further compare
the SACT template and the adult template. Although similar
spatial patterns were found, the SACT template showed
significant effects on the distributions of the statistical
results, which may be related to the performance of spatial
normalization. Looking forward, the SACT template could
contribute to future studies of white matter development in
both healthy and clinical populations. The SACT template is
publicly available now (
$https://figshare.com/articles/dataset/SACT_template/14071283$
).Keywords: Diffusion tensor template; Diffusion-weighted
MRI; School-age children; Spatial normalization.},
cin = {INM-2},
ddc = {570},
cid = {I:(DE-Juel1)INM-2-20090406},
pnm = {5253 - Neuroimaging (POF4-525)},
pid = {G:(DE-HGF)POF4-5253},
typ = {PUB:(DE-HGF)16},
pubmed = {35092576},
UT = {WOS:000749010200001},
doi = {10.1007/s12264-022-00820-1},
url = {https://juser.fz-juelich.de/record/916869},
}