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@ARTICLE{Hoenig:916872,
      author       = {Hoenig, Merle C. and Dzialas, Verena and Drzezga, Alexander
                      and van Eimeren, Thilo},
      title        = {{T}he {C}oncept of {M}otor {R}eserve in {P}arkinson's
                      {D}isease: {N}ew {W}ine in {O}ld {B}ottles?},
      journal      = {Movement disorders},
      volume       = {38},
      number       = {1},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2023-00164},
      pages        = {16-20},
      year         = {2023},
      abstract     = {Across neurodegenerative diseases, such as Parkinson's
                      disease (PD) and Alzheimer's disease (AD), a disparity
                      between the clinical expression and the extent of
                      pathophysiological burden has been observed. This has fueled
                      the establishment of resilience concepts such as cognitive
                      reserve (CR) and brain reserve (BR) at the beginning of this
                      millennium.1 Since the introduction of these concepts, a
                      plethora of studies have aimed at identifying mechanisms
                      predominantly associated with the mitigation of cognitive
                      decline despite neurodegenerative changes associated with
                      multiple sclerosis, dementia, or healthy aging (ie,
                      resilience).2, 3 In comparison, resilience mechanisms in PD
                      have received far less attention even though they seem
                      equally important given the clinical heterogeneity and long
                      prodromal phase. With the emerging concept of motor reserve
                      (MR), new avenues have opened up focusing on potential
                      neuronal processes providing resilience (ie, relative
                      preservation of motor function) in PD, which can potentially
                      be harnessed for interventional therapies. Importantly, this
                      requires a common understanding of the principles of how to
                      assess resilience in observational studies and how to
                      quantify its underlying mechanisms. Given the head start in
                      identifying pitfalls and precisely delineating the concept
                      of resilience in the AD field, the opportunity lies at hand
                      to benefit from this knowledge for investigations of MR in
                      PD.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36345092},
      UT           = {WOS:000879614200001},
      doi          = {10.1002/mds.29266},
      url          = {https://juser.fz-juelich.de/record/916872},
}