%0 Journal Article
%A Fokina, Vladislava
%A Wilke, Manuel
%A Dulle, Martin
%A Ehlert, Sascha
%A Förster, Stephan
%T Size Control of Iron Oxide Nanoparticles Synthesized by Thermal Decomposition Methods
%J The journal of physical chemistry  / C
%V 126
%N 50
%@ 1932-7447
%C Washington, DC
%I Soc.
%M FZJ-2023-00217
%P 21356 - 21367
%D 2022
%X The controlled synthesis of superparamagnetic iron oxide nanoparticles is crucial for a variety of biomedical applications. Among different synthesis routes thermal precursor decomposition methods are the most versatile, yielding monodisperse nanoparticles on the multi-gram scale. Recent in situ kinetic studies of the nucleation and growth processes during thermal decomposition routes revealed non-classical nucleation and growth paths involving amorphous precursor phases and aggregative growth steps. With the knowledge of this kinetic mechanism we systematically examined a range of different iron oxide heat-up synthesis routes to understand and conclude which methods allow good and reproducible size control over a range of relevant nanoparticle diameters. Using transmission electron microscopy (TEM) and small-angle X-ray scattering (SAXS) for the characterization of the nanoparticle size distribution we find that a set of solvents (1-octadecene, trioctylamine, docosane) provides access to a temperature range between 300 – 370°C allowing to synthesize monodisperse nanoparticles in a size range of 5 – 24 nm on large scale. We confirm that a thermal pretreatment of the iron oxide precursor is essential to achieve reproducible size control. We find that each solvent provides access to a certain temperature range, within which the variation of temperature, heating rate or precursor concentration allows to reproducibly control the nanoparticle size.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000895511200001
%R 10.1021/acs.jpcc.2c05380
%U https://juser.fz-juelich.de/record/916951