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@ARTICLE{Katzdobler:917071,
      author       = {Katzdobler, Sabrina and Nitschmann, Alexander and Barthel,
                      Henryk and Bischof, Gerard and Beyer, Leonie and Marek, Ken
                      and Song, Mengmeng and Wagemann, Olivia and Palleis, Carla
                      and Weidinger, Endy and Nack, Anne and Fietzek, Urban and
                      Kurz, Carolin and Häckert, Jan and Stapf, Theresa and
                      Ferschmann, Christian and Scheifele, Maximilian and
                      Eckenweber, Florian and Biechele, Gloria and Franzmeier,
                      Nicolai and Dewenter, Anna and Schönecker, Sonja and Saur,
                      Dorothee and Schroeter, Matthias L. and Rumpf, Jost-Julian
                      and Rullmann, Michael and Schildan, Andreas and Patt,
                      Marianne and Stephens, Andrew W. and van Eimeren, Thilo and
                      Neumaier, Bernd and Drzezga, Alexander and Danek, Adrian and
                      Classen, Joseph and Bürger, Katharina and Janowitz, Daniel
                      and Rauchmann, Boris-Stephan and Stöcklein, Sophia and
                      Perneczky, Robert and Schöberl, Florian and Zwergal,
                      Andreas and Höglinger, Günter U. and Bartenstein, Peter
                      and Villemagne, Victor and Seibyl, John and Sabri, Osama and
                      Levin, Johannes and Brendel, Matthias},
      title        = {{A}dditive value of [18{F}]{PI}-2620 perfusion imaging in
                      progressive supranuclear palsy and corticobasal syndrome},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {50},
      number       = {2},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2023-00315},
      pages        = {423 - 434},
      year         = {2023},
      abstract     = {PurposeEarly after [18F]PI-2620 PET tracer administration,
                      perfusion imaging has potential for regional assessment of
                      neuronal injury in neurodegenerative diseases. This is while
                      standard late-phase [18F]PI-2620 tau-PET is able to
                      discriminate the 4-repeat tauopathies progressive
                      supranuclear palsy and corticobasal syndrome (4RTs) from
                      disease controls and healthy controls. Here, we investigated
                      whether early-phase [18F]PI-2620 PET has an additive value
                      for biomarker based evaluation of 4RTs.MethodsSeventy-eight
                      patients with 4RTs (71 ± 7 years, 39 female), 79
                      patients with other neurodegenerative diseases
                      (67 ± 12 years, 35 female) and twelve age-matched
                      controls (69 ± 8 years, 8 female) underwent dynamic
                      (0–60 min) [18F]PI-2620 PET imaging. Regional perfusion
                      (0.5–2.5 min p.i.) and tau load (20–40 min p.i.) were
                      measured in 246 predefined brain regions
                      [standardized-uptake-value ratios (SUVr), cerebellar
                      reference]. Regional SUVr were compared between 4RTs and
                      controls by an ANOVA including false-discovery-rate (FDR,
                      p < 0.01) correction. Hypoperfusion in resulting 4RT
                      target regions was evaluated at the patient level in all
                      patients (mean value − 2SD threshold). Additionally,
                      perfusion and tau pattern expression levels were explored
                      regarding their potential discriminatory value of 4RTs
                      against other neurodegenerative disorders, including
                      validation in an independent external dataset (n = 37),
                      and correlated with clinical severity in 4RTs (PSP rating
                      scale, MoCA, activities of daily living).ResultsPatients
                      with 4RTs had significant hypoperfusion in 21/246 brain
                      regions, most dominant in thalamus, caudate nucleus, and
                      anterior cingulate cortex, fitting to the topology of the
                      4RT disease spectrum. However, single region hypoperfusion
                      was not specific regarding the discrimination of patients
                      with 4RTs against patients with other neurodegenerative
                      diseases. In contrast, perfusion pattern expression showed
                      promise for discrimination of patients with 4RTs from other
                      neurodegenerative diseases (AUC: 0.850). Discrimination by
                      the combined perfusion-tau pattern expression (AUC: 0.903)
                      exceeded that of the sole tau pattern expression (AUC:
                      0.864) and the discriminatory power of the combined
                      perfusion-tau pattern expression was replicated in the
                      external dataset (AUC: 0.917). Perfusion but not tau pattern
                      expression was associated with PSP rating scale
                      (R = 0.402; p = 0.0012) and activities of daily
                      living (R =  − 0.431;
                      p = 0.0005).Conclusion[18F]PI-2620 perfusion imaging
                      mirrors known topology of regional hypoperfusion in 4RTs.
                      Single region hypoperfusion is not specific for 4RTs, but
                      perfusion pattern expression may provide an additive value
                      for the discrimination of 4RTs from other neurodegenerative
                      diseases and correlates closer with clinical severity than
                      tau pattern expression.},
      cin          = {INM-2 / INM-5 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-5-20090406 /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525) / 5254 - Neuroscientific
                      Data Analytics and AI (POF4-525) / 5251 - Multilevel Brain
                      Organization and Variability (POF4-525) / 5252 - Brain
                      Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253 / G:(DE-HGF)POF4-5254 /
                      G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36102964},
      UT           = {WOS:000854732000001},
      doi          = {10.1007/s00259-022-05964-w},
      url          = {https://juser.fz-juelich.de/record/917071},
}