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@ARTICLE{Baagil:917091,
      author       = {Baagil, Hamzah and Hohenfeld, Christian and Habel, Ute and
                      Eickhoff, Simon B. and Gur, Raquel E. and Reetz, Kathrin and
                      Dogan, Imis},
      title        = {{N}eural correlates of impulse control behaviors in
                      {P}arkinson’s disease: {A}nalysis of multimodal imaging
                      data},
      journal      = {NeuroImage: Clinical},
      volume       = {37},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2023-00333},
      pages        = {103315 -},
      year         = {2023},
      abstract     = {Background: Impulse control behaviors (ICB) are frequently
                      observed in patients with Parkinson's disease (PD) and are
                      characterized by compulsive and repetitive behavior
                      resulting from the inability to resist internal
                      drives.Objectives: In this study, we aimed to provide a
                      better understanding of structural and functional brain
                      alterations and clinical parameters related to ICB in PD
                      patients.Methods: We utilized a dataset from the Parkinson's
                      Progression Markers Initiative including 36 patients with
                      ICB (PDICB+) compared to 76 without ICB (PDICB-) and 61
                      healthy controls (HC). Using multimodal MRI data we assessed
                      gray matter brain volume, white matter integrity, and graph
                      topological properties at rest.Results: Compared with HC,
                      PDICB+ showed reduced gray matter volume in the bilateral
                      superior and middle temporal gyrus and in the right middle
                      occipital gyrus. Compared with PDICB-, PDICB+ showed volume
                      reduction in the left anterior insula. Depression and
                      anxiety were more prevalent in PDICB+ than in PDICB- and HC.
                      In PDICB+, lower gray matter volume in the precentral gyrus
                      and medial frontal cortex, and higher axial diffusivity in
                      the superior corona radiata were related to higher
                      depression score. Both PD groups showed disrupted functional
                      topological network pattern within the cingulate cortex
                      compared with HC. PDICB+ vs PDICB- displayed reduced
                      topological network pattern in the anterior cingulate
                      cortex, insula, and nucleus accumbens.Conclusions: Our
                      results suggest that structural alterations in the insula
                      and abnormal topological connectivity pattern in the
                      salience network and the nucleus accumbens may lead to
                      impaired decision making and hypersensitivity towards reward
                      in PDICB+. Moreover, PDICB+ are more prone to suffer from
                      depression and anxiety.Keywords: Functional MRI; Impulse
                      control behaviors; Parkinson’s disease; Structural
                      magnetic resonance imaging (MRI).},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36610308},
      UT           = {WOS:000974603600001},
      doi          = {10.1016/j.nicl.2023.103315},
      url          = {https://juser.fz-juelich.de/record/917091},
}