TY  - EJOUR
AU  - Bueno, Diones
AU  - Dey, Partha Narayan
AU  - Schacht, Teresa
AU  - Wolf, Christina
AU  - Wüllner, Verena
AU  - Morpurgo, Elena
AU  - Rojas-Charry, Liliana
AU  - Sessinghaus, Lena
AU  - Leukel, Petra
AU  - Sommer, Clemens
AU  - Radyushkin, Konstantin
AU  - Schäfer, Michael K. E.
AU  - Florin, Luise
AU  - Gomez-Zepeda, David
AU  - Tenzer, Stefan
AU  - Baumgart, Jan
AU  - Stamm, Paul
AU  - Daiber, Andreas
AU  - Horta, Guilherme
AU  - Nardi, Leonardo
AU  - Vasic, Verica
AU  - Schmeisser, Michael J.
AU  - Hellwig, Andrea
AU  - Oskamp, Angela
AU  - Bauer, Andreas
AU  - Anand, Ruchika
AU  - Reichert, Andreas
AU  - Ritz, Sandra
AU  - Peper, Jonas
AU  - Silies, Marion
AU  - Frauenknecht, Katrin B. M.
AU  - Methner, Axel
TI  - NECAB2 participates in an endosomal pathway of mitochondrial stress response at striatal synapses
JO  - bioRxiv beta
CY  - Cold Spring Harbor
PB  - Cold Spring Harbor Laboratory, NY
M1  - FZJ-2023-00602
PY  - 2021
AB  - Synaptic signaling depends on ATP generated by mitochondria. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction and thus requires efficient mitochondrial quality control and repair. We found that global knockout of the neuronal calcium-binding protein 2 (NECAB2) in the mouse causes loss of striatal synapses and behavioral phenotypes related to striatal dysfunction such as reduced motivation and altered sensory gating. Striatal mitochondria from Necab2 knockout mice are more abundant and smaller. They are characterized by increased respiration and superoxide production resulting in oxidative stress. This accumulation of dysfunctional mitochondria is caused by a defective assembly of mitochondria with early endosomes in a pathway that involves the small GTPase Rab5 and its guanine nucleotide exchange factor Alsin/ALS2. NECAB2 therefore participates in an endosomal pathway of mitochondrial stress response and repair important for striatal function.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2021.02.15.431234
UR  - https://juser.fz-juelich.de/record/917388
ER  -