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@ARTICLE{Hoenig:917405,
      author       = {Hoenig, Merle C. and Drzezga, Alexander},
      title        = {{C}lear‐headed into old age: {R}esilience and resistance
                      against brain aging—{A} {PET} imaging perspective},
      journal      = {Journal of neurochemistry},
      volume       = {164},
      number       = {3},
      issn         = {0022-3042},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2023-00619},
      pages        = {325-345},
      year         = {2023},
      abstract     = {With the advances in modern medicine and the adaptation
                      towards healthier lifestyles, the average life expectancy
                      has doubled since the 1930s, with individuals born in the
                      millennium years now carrying an estimated life expectancy
                      of around 100 years. And even though many individuals around
                      the globe manage to age successfully, the prevalence of
                      aging-associated neurodegenerative diseases such as sporadic
                      Alzheimer’s disease has never been as high as nowadays.
                      The prevalence of Alzheimer’s disease is anticipated to
                      triple by 2050, increasing the societal and economic burden
                      tremendously. Despite all efforts, there is still no
                      available treatment defeating the accelerated aging process
                      as seen in this disease. Yet, given the advances in
                      neuroimaging techniques that are discussed in the current
                      Review article, such as in positron emission tomography
                      (PET) or magnetic resonance imaging (MRI), pivotal insights
                      into the heterogenous effects of aging-associated processes
                      and the contribution of distinct lifestyle and risk factors
                      already have and are still being gathered. In particular,
                      the concepts of resilience (i.e. coping with brain
                      pathology) and resistance (i.e. avoiding brain pathology)
                      have more recently been discussed as they relate to
                      mechanisms that are associated with the prolongation and/or
                      even stop of the progressive brain aging process. Better
                      understanding of the underlying mechanisms of resilience and
                      resistance may one day, hopefully, support the
                      identification of defeating mechanism against accelerating
                      aging.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5253 -
                      Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)36 / PUB:(DE-HGF)16},
      pubmed       = {35226362},
      UT           = {WOS:000782554700001},
      doi          = {10.1111/jnc.15598},
      url          = {https://juser.fz-juelich.de/record/917405},
}