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@ARTICLE{Heckner:917545,
author = {Heckner, Marisa K and Cieslik, Edna C and Patil, Kaustubh R
and Gell, Martin and Eickhoff, Simon B and Hoffstaedter,
Felix and Langner, Robert},
title = {{P}redicting executive functioning from functional brain
connectivity: network specificity and age effects},
journal = {Cerebral cortex},
volume = {33},
number = {11},
issn = {1047-3211},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2023-00748},
pages = {6495–6507},
year = {2023},
abstract = {Healthy aging is associated with altered executive
functioning (EF). Earlier studies found age-related
differences in EF performance to be partially accounted for
by changes in resting-state functional connectivity (RSFC)
within brain networks associated with EF. However, it
remains unclear which role RSFC in EF-associated networks
plays as a marker for individual differences in EF
performance. Here, we investigated to what degree individual
abilities across 3 different EF tasks can be predicted from
RSFC within EF-related, perceptuo-motor, whole-brain, and
random networks separately in young and old adults.
Specifically, we were interested if (i) young and old adults
differ in predictability depending on network or EF demand
level (high vs. low), (ii) an EF-related network outperforms
EF-unspecific networks when predicting EF abilities, and
(iii) this pattern changes with demand level. Both our uni-
and multivariate analysis frameworks analyzing interactions
between age × demand level × networks revealed overall low
prediction accuracies and a general lack of specificity
regarding neurobiological networks for predicting EF
abilities. This questions the idea of finding markers for
individual EF performance in RSFC patterns and calls for
future research replicating the current approach in
different task states, brain modalities, different, larger
samples, and with more comprehensive behavioral measures.},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {5251 - Multilevel Brain Organization and Variability
(POF4-525)},
pid = {G:(DE-HGF)POF4-5251},
typ = {PUB:(DE-HGF)16},
pubmed = {36635227},
UT = {WOS:000912678900001},
doi = {10.1093/cercor/bhac520},
url = {https://juser.fz-juelich.de/record/917545},
}