TY - EJOUR AU - Rittig, Jan G. AU - Ritzert, Martin AU - Schweidtmann, Artur M. AU - Winkler, Stefanie AU - Weber, Jana M. AU - Morsch, Philipp AU - Heufer, K. Alexander AU - Grohe, Martin AU - Mitsos, Alexander AU - Dahmen, Manuel TI - Graph Machine Learning for Design of High-Octane Fuels PB - arXiv M1 - FZJ-2023-00757 PY - 2022 AB - Fuels with high-knock resistance enable modern spark-ignition engines to achieve high efficiency and thus low CO2 emissions. Identification of molecules with desired autoignition properties indicated by a high research octane number and a high octane sensitivity is therefore of great practical relevance and can be supported by computer-aided molecular design (CAMD). Recent developments in the field of graph machine learning (graph-ML) provide novel, promising tools for CAMD. We propose a modular graph-ML CAMD framework that integrates generative graph-ML models with graph neural networks and optimization, enabling the design of molecules with desired ignition properties in a continuous molecular space. In particular, we explore the potential of Bayesian optimization and genetic algorithms in combination with generative graph-ML models. The graph-ML CAMD framework successfully identifies well-established high-octane components. It also suggests new candidates, one of which we experimentally investigate and use to illustrate the need for further auto-ignition training data. KW - Machine Learning (cs.LG) (Other) KW - FOS: Computer and information sciences (Other) LB - PUB:(DE-HGF)25 DO - DOI:10.48550/ARXIV.2206.00619 UR - https://juser.fz-juelich.de/record/917555 ER -